{"id":103,"title":"Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint","short_name":"Cyclooxygenase inhibition  5","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2026-01-11T16:56:07.000-05:00","corresponding_author":{"id":80,"created_at":"2015-03-11T13:01:45.000-04:00","updated_at":"2022-06-02T15:10:05.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":79,"event":"Inhibition, Cyclooxygenase activity","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":687,"event":"Reduced, Prostaglandin E2 concentration, hypothalamus","event_type":"KeyEvent"},{"event_id":689,"event":"Reduced, Gonadotropin releasing hormone, hypothalamus","event_type":"KeyEvent"},{"event_id":690,"event":"Reduced, Luteinizing hormone (LH), plasma ","event_type":"KeyEvent"},{"event_id":691,"event":"Reduced, Maturation inducing steroid, plasma","event_type":"KeyEvent"},{"event_id":692,"event":"Reduced, Maturation inducing steroid receptor signalling, oocyte","event_type":"KeyEvent"},{"event_id":695,"event":"Upregulated, Spindle assembly checkpoint protein Mad2-oocyte","event_type":"KeyEvent"},{"event_id":696,"event":"Increased, Chromosome misseggregation","event_type":"KeyEvent"}],"aop_aos":[{"event_id":675,"event":"Reduced, Reproductive Success","event_type":"AdverseOutcome"},{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[{"relation":377,"upstream_event_id":79,"upstream_event":"Inhibition, Cyclooxygenase activity","downstream_event_id":687,"downstream_event":"Reduced, Prostaglandin E2 concentration, hypothalamus"},{"relation":378,"upstream_event_id":687,"upstream_event":"Reduced, Prostaglandin E2 concentration, hypothalamus","downstream_event_id":689,"downstream_event":"Reduced, Gonadotropin releasing hormone, hypothalamus"},{"relation":379,"upstream_event_id":689,"upstream_event":"Reduced, Gonadotropin releasing hormone, hypothalamus","downstream_event_id":690,"downstream_event":"Reduced, Luteinizing hormone (LH), plasma "},{"relation":380,"upstream_event_id":690,"upstream_event":"Reduced, Luteinizing hormone (LH), plasma ","downstream_event_id":691,"downstream_event":"Reduced, Maturation inducing steroid, plasma"},{"relation":381,"upstream_event_id":691,"upstream_event":"Reduced, Maturation inducing steroid, plasma","downstream_event_id":692,"downstream_event":"Reduced, Maturation inducing steroid receptor signalling, oocyte"},{"relation":382,"upstream_event_id":692,"upstream_event":"Reduced, Maturation inducing steroid receptor signalling, oocyte","downstream_event_id":695,"downstream_event":"Upregulated, Spindle assembly checkpoint protein Mad2-oocyte"},{"relation":383,"upstream_event_id":695,"upstream_event":"Upregulated, Spindle assembly checkpoint protein Mad2-oocyte","downstream_event_id":696,"downstream_event":"Increased, Chromosome misseggregation"},{"relation":384,"upstream_event_id":696,"upstream_event":"Increased, Chromosome misseggregation","downstream_event_id":675,"downstream_event":"Reduced, Reproductive Success"},{"relation":1674,"upstream_event_id":675,"upstream_event":"Reduced, Reproductive Success","downstream_event_id":360,"downstream_event":"Decrease, Population growth rate"}]}