{"id":106,"title":"Chemical binding to tubulin in oocytes leading to aneuploid offspring","short_name":"Tubulin binding and aneuploidy","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-04-29T16:02:57.000-04:00","corresponding_author":{"id":332,"created_at":"2016-09-02T15:16:17.000-04:00","updated_at":"2021-04-19T16:37:04.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":124,"stressor_name":"Colchicine"},{"stressor_id":469,"stressor_name":"Vinblastine sulfate"},{"stressor_id":128,"stressor_name":"Benomyl"},{"stressor_id":127,"stressor_name":"Nocodazole"}],"aop_mies":[{"event_id":718,"event":"Binding, Tubulin","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":720,"event":"Disruption, Microtubule dynamics","event_type":"KeyEvent"},{"event_id":721,"event":"Disorganization, Meiotic Spindle","event_type":"KeyEvent"},{"event_id":752,"event":"Altered, Meiotic chromosome dynamics","event_type":"KeyEvent"},{"event_id":723,"event":"Altered, Chromosome number","event_type":"KeyEvent"}],"aop_aos":[{"event_id":728,"event":"Increase, Aneuploid offspring","event_type":"AdverseOutcome"}],"relationships":[{"relation":392,"upstream_event_id":718,"upstream_event":"Binding, Tubulin","downstream_event_id":720,"downstream_event":"Disruption, Microtubule dynamics"},{"relation":393,"upstream_event_id":720,"upstream_event":"Disruption, Microtubule dynamics","downstream_event_id":721,"downstream_event":"Disorganization, Meiotic Spindle"},{"relation":405,"upstream_event_id":721,"upstream_event":"Disorganization, Meiotic Spindle","downstream_event_id":752,"downstream_event":"Altered, Meiotic chromosome dynamics"},{"relation":406,"upstream_event_id":752,"upstream_event":"Altered, Meiotic chromosome dynamics","downstream_event_id":723,"downstream_event":"Altered, Chromosome number"},{"relation":395,"upstream_event_id":723,"upstream_event":"Altered, Chromosome number","downstream_event_id":728,"downstream_event":"Increase, Aneuploid offspring"},{"relation":396,"upstream_event_id":718,"upstream_event":"Binding, Tubulin","downstream_event_id":723,"downstream_event":"Altered, Chromosome number"}]}