{"id":111,"title":"Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)","short_name":"Decreased AR activity- Leydig cell tumors","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2026-01-11T16:56:07.000-05:00","corresponding_author":{"id":319,"created_at":"2015-08-18T16:59:44.000-04:00","updated_at":"2021-04-13T09:40:52.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":1614,"event":"Decrease, androgen receptor activation","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":743,"event":"Decreased, Testosterone binding to androgen receptor (hypothalamus)","event_type":"KeyEvent"},{"event_id":744,"event":"Increase, Hyperplasia (Leydig cells)","event_type":"KeyEvent"},{"event_id":754,"event":"Increased, Luteinizing hormone (LH) ","event_type":"KeyEvent"}],"aop_aos":[{"event_id":745,"event":"Increase, Leydig cell tumors","event_type":"AdverseOutcome"}],"relationships":[{"relation":4199,"upstream_event_id":1614,"upstream_event":"Decrease, androgen receptor activation","downstream_event_id":743,"downstream_event":"Decreased, Testosterone binding to androgen receptor (hypothalamus)"},{"relation":401,"upstream_event_id":744,"upstream_event":"Increase, Hyperplasia (Leydig cells)","downstream_event_id":745,"downstream_event":"Increase, Leydig cell tumors"},{"relation":410,"upstream_event_id":743,"upstream_event":"Decreased, Testosterone binding to androgen receptor (hypothalamus)","downstream_event_id":754,"downstream_event":"Increased, Luteinizing hormone (LH) "},{"relation":411,"upstream_event_id":754,"upstream_event":"Increased, Luteinizing hormone (LH) ","downstream_event_id":744,"downstream_event":"Increase, Hyperplasia (Leydig cells)"}]}