{"id":113,"title":"Glutamate-gated chloride channel activation leading to acute mortality","short_name":"GluCl activation to mortality","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2026-01-11T16:56:07.000-05:00","corresponding_author":{"id":6446,"created_at":"2021-10-01T10:20:53.000-04:00","updated_at":"2022-03-28T14:36:03.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":760,"event":"Activation, Glutamate-gated chloride channel","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":761,"event":"Increased, Chloride conductance","event_type":"KeyEvent"},{"event_id":763,"event":"hyperpolarisation, neuron","event_type":"KeyEvent"},{"event_id":764,"event":"N/A, Ataxia, paralysis, or hyperactivity","event_type":"KeyEvent"}],"aop_aos":[{"event_id":351,"event":"Increased Mortality","event_type":"AdverseOutcome"},{"event_id":765,"event":"Decreased, population 1","event_type":"AdverseOutcome"}],"relationships":[{"relation":418,"upstream_event_id":760,"upstream_event":"Activation, Glutamate-gated chloride channel","downstream_event_id":761,"downstream_event":"Increased, Chloride conductance"},{"relation":419,"upstream_event_id":763,"upstream_event":"hyperpolarisation, neuron","downstream_event_id":764,"downstream_event":"N/A, Ataxia, paralysis, or hyperactivity"},{"relation":420,"upstream_event_id":351,"upstream_event":"Increased Mortality","downstream_event_id":765,"downstream_event":"Decreased, population 1"},{"relation":421,"upstream_event_id":764,"upstream_event":"N/A, Ataxia, paralysis, or hyperactivity","downstream_event_id":351,"downstream_event":"Increased Mortality"},{"relation":422,"upstream_event_id":761,"upstream_event":"Increased, Chloride conductance","downstream_event_id":763,"downstream_event":"hyperpolarisation, neuron"}]}