335104-84-2IUQAXCIUEPFPSF-UHFFFAOYSA-NIUQAXCIUEPFPSF-UHFFFAOYSA-N
TembotrioneDTXSID5047037PR:P327554-hydroxyphenylpyruvate dioxygenase (rat)CHEBI:18186tyrosineCL:0000575corneal epithelial cellD010212papillomaD002277CarcinomaGO:00038684-hydroxyphenylpyruvate dioxygenase activityGO:0008219cell deathGO:0006954inflammatory responseGO:0008283cell proliferation2decreased1increasedNitisinone2016-11-29T18:42:272016-11-29T18:42:27Tembotrione2016-11-29T18:42:272016-11-29T18:42:2710116Rattus norvegicusInhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzymeInhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzymeMolecular<p>This key event commonly operates through HPPD inhibitors.
</p>2016-11-29T18:41:262016-12-03T16:37:51Increased, Plasma tyrosineIncreased, Plasma tyrosineTissueUBERON:0001969blood plasma2016-11-29T18:41:262017-09-16T10:16:13Increase, Cytotoxicity (corneal cells)Increase, Cytotoxicity (corneal cells)CellularCL:0000575corneal epithelial cell2016-11-29T18:41:262017-09-16T10:16:12Increase, Inflammation (corneal cells)Increase, Inflammation (corneal cells)CellularCL:0000575corneal epithelial cell2016-11-29T18:41:272017-09-16T10:16:12Increase, Regenerative cell proliferation (corneal cells)Increase, Regenerative cell proliferation (corneal cells)CellularCL:0000575corneal epithelial cell2016-11-29T18:41:272017-09-16T10:16:12Increase, Papillomas/carcinomas (squamous cells)Increase, Papillomas/carcinomas (squamous cells)CellularCL:0000076squamous epithelial cell2016-11-29T18:41:272017-09-16T10:16:1278362302-5fe8-41d0-acdd-406651dae8b22fc7d9dc-124a-49f5-a6f9-e12d147c2c892016-11-29T18:41:352016-12-03T16:38:002fc7d9dc-124a-49f5-a6f9-e12d147c2c89d5121427-b58f-440d-9dfe-ef945da6f83f2016-11-29T18:41:352016-12-03T16:38:00d5121427-b58f-440d-9dfe-ef945da6f83f7302d454-a26e-4105-9e26-b26a01ac6d902016-11-29T18:41:352016-12-03T16:38:007302d454-a26e-4105-9e26-b26a01ac6d9006c0166f-d484-4a87-9677-98b9cd557e252016-11-29T18:41:352016-12-03T16:38:0006c0166f-d484-4a87-9677-98b9cd557e254e1f250e-defe-43d9-8f7b-cad922eef77d2016-11-29T18:41:352016-12-03T16:38:00HPPD inhibition leading to corneal papillomas and carcinomas (in rat)HPPD- corneal papilloma/carcinoma<p>Cancer AOP group. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)</p>
Under Development: Contributions and Comments WelcomeUnder Development1.29<p>This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.</p>
adjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot SpecifiedNot SpecifiedMaleNot SpecifiedFemaleNot Specified<p>Lewis, R. W., & Botham, J. W. (2013). A review of the mode of toxicity and relevance to humans of the triketone herbicide 2-(4-methylsulfonyl-2-nitrobenzoyl)-1,3-cyclohexanedione. Crit Rev Toxicol, 43(3), 185-199. doi: 10.3109/10408444.2013.764279</p>
<p>U.S. Environmental Protection Agency. (September 7, 2007). Tembotrione Human Health Risk Assessment.: Retrieved from <a class="external free" href="http://www.regulations.gov/" rel="nofollow" target="_blank">http://www.regulations.gov/</a>.</p>
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