{"id":116,"title":"Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) ","short_name":"Cytotoxicity- renal tubular adenoma/carcinoma","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2026-01-11T16:56:07.000-05:00","corresponding_author":{"id":319,"created_at":"2015-08-18T16:59:44.000-04:00","updated_at":"2021-04-13T09:40:52.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":783,"event":"Increase, Cytotoxicity (tubular epithelial cells)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":710,"event":"Increase, Regenerative cell proliferation (tubular epithelial cells)","event_type":"KeyEvent"},{"event_id":784,"event":"Increase, Hyperplasia (tubular epithelial cells)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":713,"event":"Increase, Adenomas/carcinomas (renal tubular)","event_type":"AdverseOutcome"}],"relationships":[{"relation":445,"upstream_event_id":783,"upstream_event":"Increase, Cytotoxicity (tubular epithelial cells)","downstream_event_id":710,"downstream_event":"Increase, Regenerative cell proliferation (tubular epithelial cells)"},{"relation":446,"upstream_event_id":710,"upstream_event":"Increase, Regenerative cell proliferation (tubular epithelial cells)","downstream_event_id":784,"downstream_event":"Increase, Hyperplasia (tubular epithelial cells)"},{"relation":447,"upstream_event_id":784,"upstream_event":"Increase, Hyperplasia (tubular epithelial cells)","downstream_event_id":713,"downstream_event":"Increase, Adenomas/carcinomas (renal tubular)"}]}