67-66-3 HEDRZPFGACZZDS-UHFFFAOYSA-N HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Trichloromethane Methane, trichloro- CARBON TRICHLORIDE Chloroforme cloroformo Formyl trichloride Methane trichloride Methane,trichloro- NSC 77361 Trichloroform UN 1888 DTXSID1020306 CL:1000494 CL nephron tubule epithelial cell CL:1000507 CL kidney tubule cell D000236 MESH Adenoma D002277 MESH Carcinoma GO:0008219 GO cell death GO:0050673 GO epithelial cell proliferation MP:0004968 MP kidney epithelium hyperplasia D002292 MESH Carcinoma, Renal Cell 1 WIKI increased Chloroform 2016-11-29T18:42:27 2016-11-29T18:42:27 10116 NCBI Rattus norvegicus Increase, Cytotoxicity (tubular epithelial cells) Cellular <p>This key event can be associated with Cyp2e1-mediated bioactivation. </p> CL:1000494 CL nephron tubule epithelial cell AOPWiki 2016-11-29T18:41:27 2017-09-16T10:16:15 Increase, Regenerative cell proliferation (tubular epithelial cells) Cellular CL:1000494 CL nephron tubule epithelial cell AOPWiki 2016-11-29T18:41:26 2017-09-16T10:16:00 Increase, Hyperplasia (tubular epithelial cells) Cellular CL:1000494 CL nephron tubule epithelial cell AOPWiki 2016-11-29T18:41:27 2017-09-16T10:16:15 Increase, Adenomas/carcinomas (renal tubular) Tissue UBERON:0009773 UBERON renal tubule AOPWiki 2016-11-29T18:41:26 2017-09-16T10:16:00 AOPWiki 2016-11-29T18:41:35 2016-12-03T16:38:00 <p>Sustained regenerative cell proliferation directly leads to renal tubular hyperplasia. </p> AOPWiki 2016-11-29T18:41:35 2016-12-03T16:38:00 AOPWiki 2016-11-29T18:41:35 2016-12-03T16:38:00 Cytotoxicity- renal tubular adenoma/carcinoma Charles Wood <p>Cancer AOP Workgroup. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)</p> BY-SA 1.0 <p>This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.</p> adjacent Not Specified Not Specified adjacent Not Specified Not Specified adjacent Not Specified Not Specified Not Specified Male Not Specified <p>Golden, R. J., Holm, S. E., Robinson, D. E., Julkunen, P. H., &amp; Reese, E. A. (1997). Chloroform mode of action: implications for cancer risk assessment. Regul Toxicol Pharmacol, 26(2), 142-155. doi: 10.1006/rtph.1997.1161</p> AOPWiki 2016-11-29T18:41:16 2026-01-11T16:56:07