{"id":124,"title":"HMG-CoA reductase inhibition leading to decreased fertility","short_name":"HMGCR inhibition to male fertility","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2026-01-11T16:56:07.000-05:00","corresponding_author":{"id":120,"created_at":"2015-03-26T12:07:40.000-04:00","updated_at":"2022-02-08T14:04:58.000-05:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":804,"event":"Inhibition, HMG-CoA reductase","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":805,"event":"Decreased, mevalonate","event_type":"KeyEvent"},{"event_id":807,"event":"Decreased, cholesterol","event_type":"KeyEvent"},{"event_id":1690,"event":"Decrease, circulating testosterone levels ","event_type":"KeyEvent"},{"event_id":809,"event":"malformed, Male reproductive tract","event_type":"KeyEvent"}],"aop_aos":[{"event_id":330,"event":"Decrease, Fertility","event_type":"AdverseOutcome"}],"relationships":[{"relation":487,"upstream_event_id":804,"upstream_event":"Inhibition, HMG-CoA reductase","downstream_event_id":805,"downstream_event":"Decreased, mevalonate"},{"relation":488,"upstream_event_id":805,"upstream_event":"Decreased, mevalonate","downstream_event_id":807,"downstream_event":"Decreased, cholesterol"},{"relation":491,"upstream_event_id":809,"upstream_event":"malformed, Male reproductive tract","downstream_event_id":330,"downstream_event":"Decrease, Fertility"},{"relation":3832,"upstream_event_id":807,"upstream_event":"Decreased, cholesterol","downstream_event_id":1690,"downstream_event":"Decrease, circulating testosterone levels "},{"relation":3833,"upstream_event_id":1690,"upstream_event":"Decrease, circulating testosterone levels ","downstream_event_id":809,"downstream_event":"malformed, Male reproductive tract"}]}