{"id":138,"title":"Organic anion transporter (OAT1) inhibition leading to renal failure and mortality","short_name":"OAT1 inhibition","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2026-01-11T16:56:07.000-05:00","corresponding_author":{"id":120,"created_at":"2015-03-26T12:07:40.000-04:00","updated_at":"2022-02-08T14:04:58.000-05:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":877,"event":"Inhibition, organic anion transporter 1 (OAT1)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1096,"event":"Increased, blood uric acid concentration","event_type":"KeyEvent"},{"event_id":1097,"event":"Occurrence, renal proximal tubular necrosis","event_type":"KeyEvent"},{"event_id":1098,"event":"Increased, blood potassium concentration","event_type":"KeyEvent"},{"event_id":1102,"event":"Occurrence, tophi (urate) deposition","event_type":"KeyEvent"},{"event_id":1106,"event":"Occurrence, cardiac arrhythmia","event_type":"KeyEvent"},{"event_id":1392,"event":"Increase, Oxidative Stress ","event_type":"KeyEvent"}],"aop_aos":[{"event_id":351,"event":"Increased Mortality","event_type":"AdverseOutcome"},{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[{"relation":804,"upstream_event_id":877,"upstream_event":"Inhibition, organic anion transporter 1 (OAT1)","downstream_event_id":1096,"downstream_event":"Increased, blood uric acid concentration"},{"relation":805,"upstream_event_id":1096,"upstream_event":"Increased, blood uric acid concentration","downstream_event_id":1102,"downstream_event":"Occurrence, tophi (urate) deposition"},{"relation":806,"upstream_event_id":1102,"upstream_event":"Occurrence, tophi (urate) deposition","downstream_event_id":1097,"downstream_event":"Occurrence, renal proximal tubular necrosis"},{"relation":807,"upstream_event_id":1097,"upstream_event":"Occurrence, renal proximal tubular necrosis","downstream_event_id":1098,"downstream_event":"Increased, blood potassium concentration"},{"relation":832,"upstream_event_id":1098,"upstream_event":"Increased, blood potassium concentration","downstream_event_id":1106,"downstream_event":"Occurrence, cardiac arrhythmia"},{"relation":833,"upstream_event_id":1106,"upstream_event":"Occurrence, cardiac arrhythmia","downstream_event_id":351,"downstream_event":"Increased Mortality"},{"relation":839,"upstream_event_id":1097,"upstream_event":"Occurrence, renal proximal tubular necrosis","downstream_event_id":1096,"downstream_event":"Increased, blood uric acid concentration"},{"relation":3926,"upstream_event_id":1096,"upstream_event":"Increased, blood uric acid concentration","downstream_event_id":1392,"downstream_event":"Increase, Oxidative Stress "},{"relation":3927,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":1097,"downstream_event":"Occurrence, renal proximal tubular necrosis"}]}