{"id":15,"title":"Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations","short_name":"Alkylation of DNA leading to heritable mutations","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-04-29T16:02:55.000-04:00","corresponding_author":{"id":61,"created_at":"2013-12-16T13:44:19.000-05:00","updated_at":"2026-07-06T19:20:12.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":97,"event":"Alkylation, DNA","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":155,"event":"Inadequate DNA repair","event_type":"KeyEvent"},{"event_id":185,"event":"Increase, Mutations","event_type":"KeyEvent"}],"aop_aos":[{"event_id":336,"event":"Increase, Heritable mutations in offspring","event_type":"AdverseOutcome"}],"relationships":[{"relation":10,"upstream_event_id":97,"upstream_event":"Alkylation, DNA","downstream_event_id":155,"downstream_event":"Inadequate DNA repair"},{"relation":11,"upstream_event_id":155,"upstream_event":"Inadequate DNA repair","downstream_event_id":185,"downstream_event":"Increase, Mutations"},{"relation":12,"upstream_event_id":97,"upstream_event":"Alkylation, DNA","downstream_event_id":185,"downstream_event":"Increase, Mutations"},{"relation":13,"upstream_event_id":97,"upstream_event":"Alkylation, DNA","downstream_event_id":336,"downstream_event":"Increase, Heritable mutations in offspring"},{"relation":590,"upstream_event_id":185,"upstream_event":"Increase, Mutations","downstream_event_id":336,"downstream_event":"Increase, Heritable mutations in offspring"}]}