{"id":154,"title":"Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response","short_name":"Immunosuppression","created_at":"2016-11-29T18:41:17.000-05:00","updated_at":"2023-04-29T16:02:58.000-04:00","corresponding_author":{"id":251,"created_at":"2016-05-06T23:33:16.000-04:00","updated_at":"2023-12-22T00:23:46.000-05:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":163,"stressor_name":"Tacrolimus (also FK506)"},{"stressor_id":294,"stressor_name":"Cyclosporin"},{"stressor_id":529,"stressor_name":"Pimecrolimus"},{"stressor_id":530,"stressor_name":"Gossypol"},{"stressor_id":531,"stressor_name":"Kaempferol"},{"stressor_id":532,"stressor_name":"Dodecylbenzene sulfonate"},{"stressor_id":533,"stressor_name":"Dibefurin"},{"stressor_id":534,"stressor_name":"Ascomycin"},{"stressor_id":535,"stressor_name":"1,5-dibenzoyloxymethyl-norcantharidin"}],"aop_mies":[{"event_id":980,"event":"Inhibition, Calcineurin Activity","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":979,"event":"Interference, nuclear localization of NFAT","event_type":"KeyEvent"},{"event_id":981,"event":"Reduction, NFAT/AP-1 complex formation","event_type":"KeyEvent"},{"event_id":1202,"event":"Suppression, IL-2 and IL-4 production","event_type":"KeyEvent"}],"aop_aos":[{"event_id":984,"event":"Impairment, T-cell dependent antibody response","event_type":"AdverseOutcome"}],"relationships":[{"relation":1563,"upstream_event_id":980,"upstream_event":"Inhibition, Calcineurin Activity","downstream_event_id":979,"downstream_event":"Interference, nuclear localization of NFAT"},{"relation":1270,"upstream_event_id":979,"upstream_event":"Interference, nuclear localization of NFAT","downstream_event_id":981,"downstream_event":"Reduction, NFAT/AP-1 complex formation"},{"relation":1271,"upstream_event_id":981,"upstream_event":"Reduction, NFAT/AP-1 complex formation","downstream_event_id":1202,"downstream_event":"Suppression, IL-2 and IL-4 production"},{"relation":1272,"upstream_event_id":1202,"upstream_event":"Suppression, IL-2 and IL-4 production","downstream_event_id":984,"downstream_event":"Impairment, T-cell dependent antibody response"}]}