{"id":166,"title":"PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse","short_name":"PPARα activation and pancreatic acinar tumors","created_at":"2016-11-29T18:41:17.000-05:00","updated_at":"2026-01-11T16:56:07.000-05:00","corresponding_author":{"id":319,"created_at":"2015-08-18T16:59:44.000-04:00","updated_at":"2021-04-13T09:40:52.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":175,"stressor_name":"PERFLUOROOCTANOIC ACID"}],"aop_mies":[],"aop_kes":[{"event_id":1057,"event":"Increased, PPAR-alpha activation","event_type":"KeyEvent"},{"event_id":1058,"event":"Decreased, bile flow","event_type":"KeyEvent"},{"event_id":1059,"event":"Increased, cholestasis","event_type":"KeyEvent"},{"event_id":1060,"event":"Alteration, lipid metabolism","event_type":"KeyEvent"},{"event_id":1061,"event":"prolonged, elevation of serun CCK","event_type":"KeyEvent"},{"event_id":1062,"event":"Increased, Cellular proliferation / hyperplasia of acinar cells","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1063,"event":"Increased, Pancreatic acinar tumors","event_type":"AdverseOutcome"}],"relationships":[{"relation":760,"upstream_event_id":1057,"upstream_event":"Increased, PPAR-alpha activation","downstream_event_id":1058,"downstream_event":"Decreased, bile flow"},{"relation":761,"upstream_event_id":1057,"upstream_event":"Increased, PPAR-alpha activation","downstream_event_id":1059,"downstream_event":"Increased, cholestasis"},{"relation":762,"upstream_event_id":1057,"upstream_event":"Increased, PPAR-alpha activation","downstream_event_id":1060,"downstream_event":"Alteration, lipid metabolism"},{"relation":763,"upstream_event_id":1061,"upstream_event":"prolonged, elevation of serun CCK","downstream_event_id":1062,"downstream_event":"Increased, Cellular proliferation / hyperplasia of acinar cells"},{"relation":764,"upstream_event_id":1062,"upstream_event":"Increased, Cellular proliferation / hyperplasia of acinar cells","downstream_event_id":1063,"downstream_event":"Increased, Pancreatic acinar tumors"},{"relation":765,"upstream_event_id":1059,"upstream_event":"Increased, cholestasis","downstream_event_id":1061,"downstream_event":"prolonged, elevation of serun CCK"},{"relation":766,"upstream_event_id":1058,"upstream_event":"Decreased, bile flow","downstream_event_id":1059,"downstream_event":"Increased, cholestasis"}]}