{"id":17,"title":"Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory","short_name":"Oxidative stress and Developmental impairment in learning and memory","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2025-07-02T02:28:06.000-04:00","corresponding_author":{"id":245,"created_at":"2016-03-24T12:01:00.000-04:00","updated_at":"2026-07-01T03:26:42.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":40,"stressor_name":"Methylmercuric(II) chloride"},{"stressor_id":35,"stressor_name":"Mercuric chloride"},{"stressor_id":336,"stressor_name":"Acrylamide"}],"aop_mies":[{"event_id":1487,"event":"Binding, Thiol/seleno-proteins involved in protection against oxidative stress","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1538,"event":"Decreased protection against oxidative stress","event_type":"KeyEvent"},{"event_id":1392,"event":"Increase, Oxidative Stress ","event_type":"KeyEvent"},{"event_id":1488,"event":"Glutamate dyshomeostasis","event_type":"KeyEvent"},{"event_id":55,"event":"Increase, Cell injury/death","event_type":"KeyEvent"},{"event_id":188,"event":"Neuroinflammation","event_type":"KeyEvent"},{"event_id":1492,"event":"Tissue resident cell activation","event_type":"KeyEvent"},{"event_id":1493,"event":"Increased Pro-inflammatory mediators","event_type":"KeyEvent"},{"event_id":386,"event":"Decrease of neuronal network function","event_type":"KeyEvent"}],"aop_aos":[{"event_id":341,"event":"Impairment, Learning and memory","event_type":"AdverseOutcome"}],"relationships":[{"relation":1678,"upstream_event_id":1487,"upstream_event":"Binding, Thiol/seleno-proteins involved in protection against oxidative stress","downstream_event_id":1538,"downstream_event":"Decreased protection against oxidative stress"},{"relation":1679,"upstream_event_id":1538,"upstream_event":"Decreased protection against oxidative stress","downstream_event_id":1392,"downstream_event":"Increase, Oxidative Stress "},{"relation":1566,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":1488,"downstream_event":"Glutamate dyshomeostasis"},{"relation":1567,"upstream_event_id":1488,"upstream_event":"Glutamate dyshomeostasis","downstream_event_id":55,"downstream_event":"Increase, Cell injury/death"},{"relation":1568,"upstream_event_id":55,"upstream_event":"Increase, Cell injury/death","downstream_event_id":188,"downstream_event":"Neuroinflammation"},{"relation":1607,"upstream_event_id":55,"upstream_event":"Increase, Cell injury/death","downstream_event_id":1492,"downstream_event":"Tissue resident cell activation"},{"relation":1569,"upstream_event_id":188,"upstream_event":"Neuroinflammation","downstream_event_id":55,"downstream_event":"Increase, Cell injury/death"},{"relation":1608,"upstream_event_id":1493,"upstream_event":"Increased Pro-inflammatory mediators","downstream_event_id":55,"downstream_event":"Increase, Cell injury/death"},{"relation":1570,"upstream_event_id":55,"upstream_event":"Increase, Cell injury/death","downstream_event_id":386,"downstream_event":"Decrease of neuronal network function"},{"relation":1571,"upstream_event_id":386,"upstream_event":"Decrease of neuronal network function","downstream_event_id":341,"downstream_event":"Impairment, Learning and memory"},{"relation":1573,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":55,"downstream_event":"Increase, Cell injury/death"}]}