{"id":171,"title":"Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.","short_name":"Chronic cytotoxicity of the serous membrane and mesotheliomas.","created_at":"2016-11-29T18:41:17.000-05:00","updated_at":"2026-01-11T16:56:07.000-05:00","corresponding_author":{"id":319,"created_at":"2015-08-18T16:59:44.000-04:00","updated_at":"2021-04-13T09:40:52.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[],"aop_kes":[{"event_id":1086,"event":"persistent, cytotoxicity (pleura or peritoneum)","event_type":"KeyEvent"},{"event_id":1087,"event":"Increased, inflammation","event_type":"KeyEvent"},{"event_id":1392,"event":"Increase, Oxidative Stress ","event_type":"KeyEvent"},{"event_id":1032,"event":"Increased, secretion of local growth factors","event_type":"KeyEvent"},{"event_id":1089,"event":"Increased, Cell Proliferation (mesothelium)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1090,"event":"Increased, mesotheliomas","event_type":"AdverseOutcome"}],"relationships":[{"relation":795,"upstream_event_id":1086,"upstream_event":"persistent, cytotoxicity (pleura or peritoneum)","downstream_event_id":1087,"downstream_event":"Increased, inflammation"},{"relation":3924,"upstream_event_id":1086,"upstream_event":"persistent, cytotoxicity (pleura or peritoneum)","downstream_event_id":1392,"downstream_event":"Increase, Oxidative Stress "},{"relation":797,"upstream_event_id":1087,"upstream_event":"Increased, inflammation","downstream_event_id":1032,"downstream_event":"Increased, secretion of local growth factors"},{"relation":3925,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":1032,"downstream_event":"Increased, secretion of local growth factors"},{"relation":799,"upstream_event_id":1032,"upstream_event":"Increased, secretion of local growth factors","downstream_event_id":1089,"downstream_event":"Increased, Cell Proliferation (mesothelium)"},{"relation":800,"upstream_event_id":1089,"upstream_event":"Increased, Cell Proliferation (mesothelium)","downstream_event_id":1090,"downstream_event":"Increased, mesotheliomas"}]}