{"id":176,"title":"Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis","short_name":"NIS inhib alters metamorphosis","created_at":"2016-11-29T18:41:17.000-05:00","updated_at":"2026-01-11T16:56:07.000-05:00","corresponding_author":{"id":142,"created_at":"2015-07-24T10:53:28.000-04:00","updated_at":"2021-07-13T15:26:42.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":66,"stressor_name":"Perchlorate"}],"aop_mies":[{"event_id":424,"event":"Inhibition, Na+/I- symporter (NIS)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":425,"event":"Decrease of Thyroidal iodide","event_type":"KeyEvent"},{"event_id":277,"event":"Thyroid hormone synthesis, Decreased","event_type":"KeyEvent"},{"event_id":281,"event":" Thyroxine (T4) in serum, Decreased","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1101,"event":"Altered, Amphibian metamorphosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":2424,"upstream_event_id":424,"upstream_event":"Inhibition, Na+/I- symporter (NIS)","downstream_event_id":425,"downstream_event":"Decrease of Thyroidal iodide"},{"relation":2427,"upstream_event_id":424,"upstream_event":"Inhibition, Na+/I- symporter (NIS)","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"},{"relation":2425,"upstream_event_id":425,"upstream_event":"Decrease of Thyroidal iodide","downstream_event_id":277,"downstream_event":"Thyroid hormone synthesis, Decreased"},{"relation":2428,"upstream_event_id":281,"upstream_event":" Thyroxine (T4) in serum, Decreased","downstream_event_id":1101,"downstream_event":"Altered, Amphibian metamorphosis"},{"relation":2426,"upstream_event_id":277,"upstream_event":"Thyroid hormone synthesis, Decreased","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"}]}