298-46-4FFGPTBGBLSHEPO-UHFFFAOYSA-NFFGPTBGBLSHEPO-UHFFFAOYSA-N
CarbamazepineCarbazepine
5H-Dibenz[b,f]azepine-5-carboxamide
5-Carbamoyl-5H-dibenz[b,f]azepine
5H-Dibenzo [b,f] azepine-5-carboxamide
Amizepin
Calepsin
Carbamazepen
Carbamazepin
carbamazepina
Carbatrol
Carbelan
Finlepsin
Geigy 32883
Karbamazepin
Karbelex
Karberol
Neurotol
Neurotop
NSC 169864
Stazepine
Tegretal
Tegretol
Tegretol XR
Telesmin
Timonil
DTXSID402273197240-79-4KJADKKWYZYXHBB-XBWDGYHZSA-NKJADKKWYZYXHBB-XBWDGYHZSA-N
Topiramateβ-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, sulfamate
2,3:4,5-Bis-O-(1-methylethylidene) β-D-fructopyranose sulfamate
Epitoma
Epitomax
Topamac
Topamax
Topimax
Topomax
β-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate
DTXSID80236881951-25-3IYIKLHRQXLHMJQ-UHFFFAOYSA-NIYIKLHRQXLHMJQ-UHFFFAOYSA-N
AmiodaroneMethanone, (2-butyl-3-benzofuranyl)[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]-
2-Butyl-3-[3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl]benzofuran
2-Butyl-3-benzofuranyl p-[(2-diethylamino)ethoxy]-m,m-diiodophenyl ketone
2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran
Amidorone
Amiodaron
amiodarona
Ancaron
Ketone, 2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl
Sedacoron
Sedacorone
DTXSID702259268291-97-4UBQNRHZMVUUOMG-UHFFFAOYSA-NUBQNRHZMVUUOMG-UHFFFAOYSA-N
Zonisamide1,2-Benzisoxazole-3-methanesulfonamide
DTXSID9046023137-58-6NNJVILVZKWQKPM-UHFFFAOYSA-NNNJVILVZKWQKPM-UHFFFAOYSA-N
LidocaineAcetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2',6'-Acetoxylidide, 2-(diethylamino)-
2-Diethylamino-2,6'-acetoxylidide
Anbesol
Anestacon
Aritmal
Cuivasil
Dalcaine
Duncaine
ELA-Max
Esracaine
Isicaina
Isicaine
Jetocaine
Leostesin
Lida-Mantle
Lidocadren
Lidocain
lidocaina
Lidoderm
Lignocaine
Maricaine
NSC 40030
Remicaine
Rucaina
Solarcaine
Solcain
Trachisan
Xycaine
Xylestesin
Xylocain
XYLOCAINE
Xylocitin
α-Diethylamino-2,6-acetoxylidide
DTXSID1045166PR:000002095sodium channel protein type 1 subunit alphaCHEBI:29101sodium(1+)CHEBI:16865gamma-aminobutyric acidGO:0019871sodium channel inhibitor activityGO:0023052signalingGO:0006810transport2decreasedCarbamazepine2016-11-29T18:42:272016-11-29T18:42:27Topiramate2016-11-29T18:42:272016-11-29T18:42:27Tetrodotoxin2016-11-29T18:42:272016-11-29T18:42:27Amiodarone2016-11-29T18:42:272016-11-29T18:42:27Phenytoin2016-11-29T18:42:272016-11-29T18:42:27Valproate2016-11-29T18:42:272016-11-29T18:42:27Zonisamide2016-11-29T18:42:272016-11-29T18:42:27Lidocaine2016-11-29T18:42:272016-11-29T18:42:27Inhibition, sodium channelInhibition, sodium channelMolecular<p>Voltage-gated sodium channels consist of an alpha subunit and auxiliary beta subunits. The alpha subunit is the ion pore-forming component of the channel and is organized into four homologous domains (I- IV), each with six trans-membrane alpha helices (S1-S6). Between the S5 and S6 segments, there is a pore loop which is a primary target for anti-epileptic drugs. The segments between S5 and S6 in each of the four domains create extracellular pore loops. Amino acid changes in the poor loops within domains II and IV determine if the ion channel is sensitive to sodium or calcium ions. Anti-epileptic, anti-arrhythmic and anesthetics all may bind this same site, but their action may be voltage-specific. For example, phenytoin is an ineffective block of hyperpolarized (e.g., -100mV) sodium channels, but is more effective at blocking progressively depolarized potentials (e.g., -80 to -30 mV).
</p><p><em>
Voltage-clamp recordings of sodium currents is a general means of detection. ToxCast assay NVS_IC_rNaCh_site 2 also measures binding to the sodium channel receptor.
</em>
</p>CL:0000255eukaryotic cell<p>Ragsdale, D.S. and Avoli, M. 1998. Sodium channels as molecular targets for antiepileptic drugs. Brain Research Reviews 26:16-28.
</p><p>Pless, S.A., Galpin, J.D., Frankel, A., and Ahern, C.A. 2011. Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels. Nat Commun 2:351.
</p>2016-11-29T18:41:252017-09-16T10:15:48Decreased, sodium conductance 2Decreased, sodium conductance 2Cellular2016-11-29T18:41:302016-12-03T16:37:53Decreased, GABA releaseDecreased, GABA releaseCellular2016-11-29T18:41:302016-12-03T16:37:532936db26-d3e5-4cee-9349-85ce3b6e0e1b8f3bae62-f92f-487c-b66f-9280441e47bb2016-11-29T18:41:372016-12-03T16:38:068f3bae62-f92f-487c-b66f-9280441e47bbd242c088-8ead-4a3d-a0f9-cedc55c794202016-11-29T18:41:372016-12-03T16:38:06Sodium channel (Nav1.1) inhibition leading to population declineNav1.1 inhibition to population decline<p>Kellie Fay</p>
Under Development: Contributions and Comments WelcomeUnder Development1.29adjacentNot SpecifiedNot SpecifiedadjacentNot SpecifiedNot Specified2016-11-29T18:41:172023-04-29T16:02:59