{"id":207,"title":"NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans","short_name":"NADPH oxidase activation leading to reproductive failure","created_at":"2017-02-15T03:09:24.000-05:00","updated_at":"2025-04-03T17:33:03.000-04:00","corresponding_author":{"id":392,"created_at":"2017-02-08T10:41:54.000-05:00","updated_at":"2025-08-14T09:46:15.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":252,"stressor_name":"Silver nanoparticles"}],"aop_mies":[{"event_id":1174,"event":"Activation, NADPH Oxidase","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1115,"event":"Increase, Reactive oxygen species","event_type":"KeyEvent"},{"event_id":1279,"event":"Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK","event_type":"KeyEvent"},{"event_id":1280,"event":"Activation, HIF-1","event_type":"KeyEvent"},{"event_id":1281,"event":"Increased, DNA Damage-Repair","event_type":"KeyEvent"},{"event_id":177,"event":"Increase, Mitochondrial dysfunction","event_type":"KeyEvent"},{"event_id":1262,"event":"Apoptosis","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1277,"event":"Reproductive failure","event_type":"AdverseOutcome"}],"relationships":[{"relation":4360,"upstream_event_id":1174,"upstream_event":"Activation, NADPH Oxidase","downstream_event_id":1115,"downstream_event":"Increase, Reactive oxygen species"},{"relation":4361,"upstream_event_id":1279,"upstream_event":"Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK","downstream_event_id":1115,"downstream_event":"Increase, Reactive oxygen species"},{"relation":1099,"upstream_event_id":1279,"upstream_event":"Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK","downstream_event_id":1281,"downstream_event":"Increased, DNA Damage-Repair"},{"relation":3788,"upstream_event_id":1279,"upstream_event":"Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK","downstream_event_id":177,"downstream_event":"Increase, Mitochondrial dysfunction"},{"relation":1101,"upstream_event_id":1279,"upstream_event":"Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK","downstream_event_id":1280,"downstream_event":"Activation, HIF-1"},{"relation":1102,"upstream_event_id":1280,"upstream_event":"Activation, HIF-1","downstream_event_id":1262,"downstream_event":"Apoptosis"},{"relation":1103,"upstream_event_id":1281,"upstream_event":"Increased, DNA Damage-Repair","downstream_event_id":1262,"downstream_event":"Apoptosis"},{"relation":3789,"upstream_event_id":177,"upstream_event":"Increase, Mitochondrial dysfunction","downstream_event_id":1262,"downstream_event":"Apoptosis"},{"relation":1105,"upstream_event_id":1262,"upstream_event":"Apoptosis","downstream_event_id":1277,"downstream_event":"Reproductive failure"}]}