{"id":21,"title":"Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2","short_name":"AhR mediated mortality, via COX-2","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-04-29T16:02:55.000-04:00","corresponding_author":{"id":220,"created_at":"2014-01-14T10:18:33.000-05:00","updated_at":"2026-05-28T10:18:45.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":249,"stressor_name":"2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)"}],"aop_mies":[{"event_id":18,"event":"Activation, AhR","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":944,"event":"dimerization, AHR/ARNT","event_type":"KeyEvent"},{"event_id":1269,"event":"Increase, COX-2 expression","event_type":"KeyEvent"},{"event_id":317,"event":"Altered, Cardiovascular development/function","event_type":"KeyEvent"},{"event_id":947,"event":"Increase, Early Life Stage Mortality","event_type":"KeyEvent"}],"aop_aos":[],"relationships":[{"relation":1617,"upstream_event_id":18,"upstream_event":"Activation, AhR","downstream_event_id":947,"downstream_event":"Increase, Early Life Stage Mortality"},{"relation":1086,"upstream_event_id":18,"upstream_event":"Activation, AhR","downstream_event_id":944,"downstream_event":"dimerization, AHR/ARNT"},{"relation":1087,"upstream_event_id":944,"upstream_event":"dimerization, AHR/ARNT","downstream_event_id":1269,"downstream_event":"Increase, COX-2 expression"},{"relation":1088,"upstream_event_id":1269,"upstream_event":"Increase, COX-2 expression","downstream_event_id":317,"downstream_event":"Altered, Cardiovascular development/function"},{"relation":1616,"upstream_event_id":317,"upstream_event":"Altered, Cardiovascular development/function","downstream_event_id":947,"downstream_event":"Increase, Early Life Stage Mortality"}]}