<?xml version="1.0" encoding="UTF-8"?>
<data xmlns="http://www.aopkb.org/aop-xml">
  <stressor id="b35c6c23-b6d5-46cd-9526-3db5b5f56534">
    <name>NSAID (Nonsteroidal anti-inflammatory drug) inhibits PTGS2</name>
    <description></description>
    <exposure-characterization></exposure-characterization>
    <creation-timestamp>2017-06-02T10:52:11</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:52:11</last-modification-timestamp>
  </stressor>
  <key-event id="dca32844-b621-45ce-9632-e7b320c393b0">
    <title>Reduced, PTGS2 function</title>
    <short-name>Reduced, PTGS2 function</short-name>
    <biological-organization-level>Cellular</biological-organization-level>
    <description></description>
    <measurement-methodology></measurement-methodology>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <applicability>
    </applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:54:10</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:54:10</last-modification-timestamp>
  </key-event>
  <key-event id="d4a0844b-5c6e-4ca4-ac8f-299739e7db30">
    <title>Activated, gastric ulcer formation</title>
    <short-name>Activated, gastric ulcer formation</short-name>
    <biological-organization-level>Organ</biological-organization-level>
    <description></description>
    <measurement-methodology></measurement-methodology>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <applicability>
    </applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-04-17T10:47:40</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:26:25</last-modification-timestamp>
  </key-event>
  <key-event id="59363877-ff07-4d2f-acb1-541d912beeca">
    <title>Decreased, angiogenesis</title>
    <short-name>Decreased, angiogenesis</short-name>
    <biological-organization-level>Tissue</biological-organization-level>
    <description></description>
    <measurement-methodology></measurement-methodology>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <applicability>
    </applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:55:43</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:55:43</last-modification-timestamp>
  </key-event>
  <key-event id="300b6e98-f5a7-468c-8c4a-e9f0dbf3aee9">
    <title>Increased, leukocyte adherence</title>
    <short-name>Increased, leukocyte adherence</short-name>
    <biological-organization-level>Tissue</biological-organization-level>
    <description></description>
    <measurement-methodology></measurement-methodology>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <applicability>
    </applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:57:09</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:57:09</last-modification-timestamp>
  </key-event>
  <key-event id="84c1d1b4-a6c9-441d-963b-f31db724e1d5">
    <title>Increased, leukocyte activation</title>
    <short-name>Increased, leukocyte activation</short-name>
    <biological-organization-level>Tissue</biological-organization-level>
    <description></description>
    <measurement-methodology></measurement-methodology>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <applicability>
    </applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:57:39</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:57:39</last-modification-timestamp>
  </key-event>
  <key-event-relationship id="1811edcf-1b96-4590-8b03-68e1ffe4c699">
    <title>
      <upstream-id>dca32844-b621-45ce-9632-e7b320c393b0</upstream-id>
      <downstream-id>59363877-ff07-4d2f-acb1-541d912beeca</downstream-id>
    </title>
    <description></description>
    <evidence-collection-strategy/>
    <weight-of-evidence>
      <value></value>
      <biological-plausibility></biological-plausibility>
      <emperical-support-linkage></emperical-support-linkage>
      <uncertainties-or-inconsistencies></uncertainties-or-inconsistencies>
    </weight-of-evidence>
    <known-modulating-factors/>
    <quantitative-understanding>
      <description></description>
      <response-response-relationship/>
      <time-scale/>
      <feedforward-feedback-loops/>
    </quantitative-understanding>
    <applicability>
    </applicability>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:58:00</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:58:00</last-modification-timestamp>
  </key-event-relationship>
  <key-event-relationship id="6be431d4-c6bd-44ee-b2d1-d0c6242f65d9">
    <title>
      <upstream-id>59363877-ff07-4d2f-acb1-541d912beeca</upstream-id>
      <downstream-id>d4a0844b-5c6e-4ca4-ac8f-299739e7db30</downstream-id>
    </title>
    <description></description>
    <evidence-collection-strategy/>
    <weight-of-evidence>
      <value></value>
      <biological-plausibility></biological-plausibility>
      <emperical-support-linkage></emperical-support-linkage>
      <uncertainties-or-inconsistencies></uncertainties-or-inconsistencies>
    </weight-of-evidence>
    <known-modulating-factors/>
    <quantitative-understanding>
      <description></description>
      <response-response-relationship/>
      <time-scale/>
      <feedforward-feedback-loops/>
    </quantitative-understanding>
    <applicability>
    </applicability>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:58:17</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:58:17</last-modification-timestamp>
  </key-event-relationship>
  <key-event-relationship id="2e6ed914-4510-4d7b-92e2-05e1cd3628fe">
    <title>
      <upstream-id>dca32844-b621-45ce-9632-e7b320c393b0</upstream-id>
      <downstream-id>300b6e98-f5a7-468c-8c4a-e9f0dbf3aee9</downstream-id>
    </title>
    <description></description>
    <evidence-collection-strategy/>
    <weight-of-evidence>
      <value></value>
      <biological-plausibility></biological-plausibility>
      <emperical-support-linkage></emperical-support-linkage>
      <uncertainties-or-inconsistencies></uncertainties-or-inconsistencies>
    </weight-of-evidence>
    <known-modulating-factors/>
    <quantitative-understanding>
      <description></description>
      <response-response-relationship/>
      <time-scale/>
      <feedforward-feedback-loops/>
    </quantitative-understanding>
    <applicability>
    </applicability>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:58:40</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:58:40</last-modification-timestamp>
  </key-event-relationship>
  <key-event-relationship id="42f1ba7b-85ec-40dc-9016-e863ff9c512e">
    <title>
      <upstream-id>300b6e98-f5a7-468c-8c4a-e9f0dbf3aee9</upstream-id>
      <downstream-id>84c1d1b4-a6c9-441d-963b-f31db724e1d5</downstream-id>
    </title>
    <description></description>
    <evidence-collection-strategy/>
    <weight-of-evidence>
      <value></value>
      <biological-plausibility></biological-plausibility>
      <emperical-support-linkage></emperical-support-linkage>
      <uncertainties-or-inconsistencies></uncertainties-or-inconsistencies>
    </weight-of-evidence>
    <known-modulating-factors/>
    <quantitative-understanding>
      <description></description>
      <response-response-relationship/>
      <time-scale/>
      <feedforward-feedback-loops/>
    </quantitative-understanding>
    <applicability>
    </applicability>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:58:51</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:58:51</last-modification-timestamp>
  </key-event-relationship>
  <key-event-relationship id="dd6259cf-1e13-4eeb-bdc4-dcdb92eda2a4">
    <title>
      <upstream-id>84c1d1b4-a6c9-441d-963b-f31db724e1d5</upstream-id>
      <downstream-id>d4a0844b-5c6e-4ca4-ac8f-299739e7db30</downstream-id>
    </title>
    <description></description>
    <evidence-collection-strategy/>
    <weight-of-evidence>
      <value></value>
      <biological-plausibility></biological-plausibility>
      <emperical-support-linkage></emperical-support-linkage>
      <uncertainties-or-inconsistencies></uncertainties-or-inconsistencies>
    </weight-of-evidence>
    <known-modulating-factors/>
    <quantitative-understanding>
      <description></description>
      <response-response-relationship/>
      <time-scale/>
      <feedforward-feedback-loops/>
    </quantitative-understanding>
    <applicability>
    </applicability>
    <evidence-supporting-taxonomic-applicability></evidence-supporting-taxonomic-applicability>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:59:06</creation-timestamp>
    <last-modification-timestamp>2017-06-02T10:59:06</last-modification-timestamp>
  </key-event-relationship>
  <aop id="412c075e-a9f7-4ced-9310-42296f0ecd99">
    <title>NSAID induced PTGS2 inactivation to gastric ulcer</title>
    <short-name>NSAID induced PTGS2 inactivation to gastric ulcer</short-name>
    <point-of-contact>Lyle Burgoon</point-of-contact>
    <authors></authors>
    <coaches>
    </coaches>
    <external_links>
    </external_links>
    <status>
      <wiki-license>Open for adoption</wiki-license>
    </status>
    <oecd-project></oecd-project>
    <handbook-version>1.0</handbook-version>
    <abstract></abstract>
    <molecular-initiating-event key-event-id="dca32844-b621-45ce-9632-e7b320c393b0">
      <evidence-supporting-chemical-initiation></evidence-supporting-chemical-initiation>
    </molecular-initiating-event>
    <key-events>
      <key-event key-event-id="59363877-ff07-4d2f-acb1-541d912beeca"/>
      <key-event key-event-id="300b6e98-f5a7-468c-8c4a-e9f0dbf3aee9"/>
      <key-event key-event-id="84c1d1b4-a6c9-441d-963b-f31db724e1d5"/>
    </key-events>
    <adverse-outcome key-event-id="d4a0844b-5c6e-4ca4-ac8f-299739e7db30">
      <examples></examples>
    </adverse-outcome>
    <key-event-relationships>
      <relationship id="1811edcf-1b96-4590-8b03-68e1ffe4c699">
        <adjacency>adjacent</adjacency>
        <quantitative-understanding-value>Not Specified</quantitative-understanding-value>
        <evidence>Not Specified</evidence>
      </relationship>
      <relationship id="6be431d4-c6bd-44ee-b2d1-d0c6242f65d9">
        <adjacency>adjacent</adjacency>
        <quantitative-understanding-value>Not Specified</quantitative-understanding-value>
        <evidence>Not Specified</evidence>
      </relationship>
      <relationship id="2e6ed914-4510-4d7b-92e2-05e1cd3628fe">
        <adjacency>adjacent</adjacency>
        <quantitative-understanding-value>Not Specified</quantitative-understanding-value>
        <evidence>Not Specified</evidence>
      </relationship>
      <relationship id="42f1ba7b-85ec-40dc-9016-e863ff9c512e">
        <adjacency>adjacent</adjacency>
        <quantitative-understanding-value>Not Specified</quantitative-understanding-value>
        <evidence>Not Specified</evidence>
      </relationship>
      <relationship id="dd6259cf-1e13-4eeb-bdc4-dcdb92eda2a4">
        <adjacency>adjacent</adjacency>
        <quantitative-understanding-value>Not Specified</quantitative-understanding-value>
        <evidence>Not Specified</evidence>
      </relationship>
    </key-event-relationships>
    <applicability>
    </applicability>
    <overall-assessment>
      <description></description>
      <applicability></applicability>
      <key-event-essentiality-summary></key-event-essentiality-summary>
      <weight-of-evidence-summary></weight-of-evidence-summary>
      <known-modulating-factors/>
      <quantitative-considerations></quantitative-considerations>
    </overall-assessment>
    <potential-applications></potential-applications>
    <aop-stressors>
      <aop-stressor stressor-id="b35c6c23-b6d5-46cd-9526-3db5b5f56534">
        <evidence>Not Specified</evidence>
      </aop-stressor>
    </aop-stressors>
    <references></references>
    <source>AOPWiki</source>
    <creation-timestamp>2017-06-02T10:50:59</creation-timestamp>
    <last-modification-timestamp>2023-04-29T16:03:00</last-modification-timestamp>
  </aop>
  <vendor-specific id="ad27428c-6dbf-4262-92fe-81f732415c0e" name="AopWiki" version="2026-04-13 11:51:36 +0000">
    <stressor-reference id="b35c6c23-b6d5-46cd-9526-3db5b5f56534" aop-wiki-id="298"/>
    <key-event-reference id="dca32844-b621-45ce-9632-e7b320c393b0" aop-wiki-id="1408"/>
    <key-event-reference id="d4a0844b-5c6e-4ca4-ac8f-299739e7db30" aop-wiki-id="1385"/>
    <key-event-reference id="59363877-ff07-4d2f-acb1-541d912beeca" aop-wiki-id="1409"/>
    <key-event-reference id="300b6e98-f5a7-468c-8c4a-e9f0dbf3aee9" aop-wiki-id="1410"/>
    <key-event-reference id="84c1d1b4-a6c9-441d-963b-f31db724e1d5" aop-wiki-id="1411"/>
    <key-event-relationship-reference id="1811edcf-1b96-4590-8b03-68e1ffe4c699" aop-wiki-id="1541"/>
    <key-event-relationship-reference id="6be431d4-c6bd-44ee-b2d1-d0c6242f65d9" aop-wiki-id="1542"/>
    <key-event-relationship-reference id="2e6ed914-4510-4d7b-92e2-05e1cd3628fe" aop-wiki-id="1543"/>
    <key-event-relationship-reference id="42f1ba7b-85ec-40dc-9016-e863ff9c512e" aop-wiki-id="1544"/>
    <key-event-relationship-reference id="dd6259cf-1e13-4eeb-bdc4-dcdb92eda2a4" aop-wiki-id="1545"/>
    <aop-reference id="412c075e-a9f7-4ced-9310-42296f0ecd99" aop-wiki-id="228"/>
  </vendor-specific>
</data>
