{"id":237,"title":"Substance interaction with lung resident cell membrane components leading to atherosclerosis","short_name":"Interaction with lung cells leading to atherosclerosis","created_at":"2017-06-29T01:37:35.000-04:00","updated_at":"2026-05-01T07:46:01.000-04:00","corresponding_author":{"id":15664,"created_at":"2023-01-26T07:20:45.000-05:00","updated_at":"2026-05-29T02:49:10.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":376,"stressor_name":"Lipopolysaccharride"},{"stressor_id":255,"stressor_name":"Graphene oxide nanoparticles"},{"stressor_id":318,"stressor_name":"Carbon nanotubes"},{"stressor_id":377,"stressor_name":"Insoluble nano-sized particles"},{"stressor_id":378,"stressor_name":"Virus"}],"aop_mies":[{"event_id":1495,"event":"Substance interaction with the lung resident cell membrane components","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1496,"event":"Increased, secretion of proinflammatory mediators","event_type":"KeyEvent"},{"event_id":1438,"event":"Transcription of genes encoding acute phase proteins, Increased","event_type":"KeyEvent"},{"event_id":1439,"event":"Systemic acute phase response","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1443,"event":"Atherosclerosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":3379,"upstream_event_id":1495,"upstream_event":"Substance interaction with the lung resident cell membrane components","downstream_event_id":1496,"downstream_event":"Increased, secretion of proinflammatory mediators"},{"relation":3515,"upstream_event_id":1495,"upstream_event":"Substance interaction with the lung resident cell membrane components","downstream_event_id":1438,"downstream_event":"Transcription of genes encoding acute phase proteins, Increased"},{"relation":3380,"upstream_event_id":1496,"upstream_event":"Increased, secretion of proinflammatory mediators","downstream_event_id":1438,"downstream_event":"Transcription of genes encoding acute phase proteins, Increased"},{"relation":3516,"upstream_event_id":1495,"upstream_event":"Substance interaction with the lung resident cell membrane components","downstream_event_id":1439,"downstream_event":"Systemic acute phase response"},{"relation":3637,"upstream_event_id":1496,"upstream_event":"Increased, secretion of proinflammatory mediators","downstream_event_id":1439,"downstream_event":"Systemic acute phase response"},{"relation":3381,"upstream_event_id":1438,"upstream_event":"Transcription of genes encoding acute phase proteins, Increased","downstream_event_id":1439,"downstream_event":"Systemic acute phase response"},{"relation":3517,"upstream_event_id":1495,"upstream_event":"Substance interaction with the lung resident cell membrane components","downstream_event_id":1443,"downstream_event":"Atherosclerosis"},{"relation":3382,"upstream_event_id":1439,"upstream_event":"Systemic acute phase response","downstream_event_id":1443,"downstream_event":"Atherosclerosis"}]}