{"id":256,"title":"Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity","short_name":"Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity","created_at":"2017-10-25T07:15:19.000-04:00","updated_at":"2024-02-28T14:53:52.000-05:00","corresponding_author":{"id":374,"created_at":"2017-01-17T08:38:15.000-05:00","updated_at":"2021-04-13T09:40:45.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":322,"stressor_name":"Tenofovir"},{"stressor_id":323,"stressor_name":"Tenofovir disoproxil fumarate"},{"stressor_id":324,"stressor_name":"Adefovir"},{"stressor_id":325,"stressor_name":"Adefovir dipivoxil"},{"stressor_id":326,"stressor_name":"Cidofovir"}],"aop_mies":[{"event_id":1481,"event":"Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1482,"event":"Depletion, mtDNA ","event_type":"KeyEvent"},{"event_id":177,"event":"Increase, Mitochondrial dysfunction","event_type":"KeyEvent"},{"event_id":709,"event":"Increase, Cytotoxicity (renal tubular cell)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":814,"event":"Occurrence, Kidney toxicity","event_type":"AdverseOutcome"}],"relationships":[{"relation":1551,"upstream_event_id":1481,"upstream_event":"Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)","downstream_event_id":1482,"downstream_event":"Depletion, mtDNA "},{"relation":3748,"upstream_event_id":1482,"upstream_event":"Depletion, mtDNA ","downstream_event_id":177,"downstream_event":"Increase, Mitochondrial dysfunction"},{"relation":3749,"upstream_event_id":177,"upstream_event":"Increase, Mitochondrial dysfunction","downstream_event_id":709,"downstream_event":"Increase, Cytotoxicity (renal tubular cell)"},{"relation":1554,"upstream_event_id":709,"upstream_event":"Increase, Cytotoxicity (renal tubular cell)","downstream_event_id":814,"downstream_event":"Occurrence, Kidney toxicity"}]}