{"id":271,"title":"Inhibition of thyroid peroxidase leading to impaired fertility in fish","short_name":"TPO inhibition and impaired fertility ","created_at":"2018-09-18T20:33:14.000-04:00","updated_at":"2023-06-07T05:33:54.000-04:00","corresponding_author":{"id":622,"created_at":"2018-04-24T00:57:36.000-04:00","updated_at":"2023-01-25T18:05:36.000-05:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":48,"stressor_name":"Propylthiouracil"},{"stressor_id":37,"stressor_name":"Methimazole"},{"stressor_id":25,"stressor_name":"Ethylene thiourea"}],"aop_mies":[{"event_id":279,"event":"Thyroperoxidase, Inhibition","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":277,"event":"Thyroid hormone synthesis, Decreased","event_type":"KeyEvent"},{"event_id":219,"event":"Reduction, Plasma 17beta-estradiol concentrations","event_type":"KeyEvent"},{"event_id":221,"event":"Reduction, Plasma vitellogenin concentrations","event_type":"KeyEvent"}],"aop_aos":[{"event_id":78,"event":"Reduction, Cumulative fecundity and spawning","event_type":"AdverseOutcome"}],"relationships":[{"relation":1680,"upstream_event_id":279,"upstream_event":"Thyroperoxidase, Inhibition","downstream_event_id":277,"downstream_event":"Thyroid hormone synthesis, Decreased"},{"relation":1681,"upstream_event_id":277,"upstream_event":"Thyroid hormone synthesis, Decreased","downstream_event_id":219,"downstream_event":"Reduction, Plasma 17beta-estradiol concentrations"},{"relation":1682,"upstream_event_id":219,"upstream_event":"Reduction, Plasma 17beta-estradiol concentrations","downstream_event_id":221,"downstream_event":"Reduction, Plasma vitellogenin concentrations"},{"relation":1683,"upstream_event_id":221,"upstream_event":"Reduction, Plasma vitellogenin concentrations","downstream_event_id":78,"downstream_event":"Reduction, Cumulative fecundity and spawning"}]}