{"id":296,"title":"Oxidative DNA damage leading to chromosomal aberrations and mutations","short_name":"Oxidative DNA damage, chromosomal aberrations and mutations","created_at":"2019-05-19T16:13:15.000-04:00","updated_at":"2023-04-29T16:03:02.000-04:00","corresponding_author":{"id":61,"created_at":"2013-12-16T13:44:19.000-05:00","updated_at":"2023-01-09T20:14:28.000-05:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":454,"stressor_name":"Hydrogen peroxide"},{"stressor_id":455,"stressor_name":"Potassium bromate"},{"stressor_id":451,"stressor_name":"Ionizing Radiation"},{"stressor_id":456,"stressor_name":"Cadmium chloride"},{"stressor_id":457,"stressor_name":"tert-Butyl hydroperoxide"},{"stressor_id":303,"stressor_name":"Reactive oxygen species"},{"stressor_id":514,"stressor_name":"Hydroquinone"},{"stressor_id":515,"stressor_name":"4-Nitroquinoline 1-oxide"}],"aop_mies":[{"event_id":1634,"event":"Increase, Oxidative DNA damage","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":155,"event":"Inadequate DNA repair","event_type":"KeyEvent"},{"event_id":1635,"event":"Increase, DNA strand breaks","event_type":"KeyEvent"}],"aop_aos":[{"event_id":185,"event":"Increase, Mutations","event_type":"AdverseOutcome"},{"event_id":1636,"event":"Increase, Chromosomal aberrations","event_type":"AdverseOutcome"}],"relationships":[{"relation":1907,"upstream_event_id":1634,"upstream_event":"Increase, Oxidative DNA damage","downstream_event_id":155,"downstream_event":"Inadequate DNA repair"},{"relation":1905,"upstream_event_id":1634,"upstream_event":"Increase, Oxidative DNA damage","downstream_event_id":1635,"downstream_event":"Increase, DNA strand breaks"},{"relation":1901,"upstream_event_id":155,"upstream_event":"Inadequate DNA repair","downstream_event_id":1635,"downstream_event":"Increase, DNA strand breaks"},{"relation":1906,"upstream_event_id":1634,"upstream_event":"Increase, Oxidative DNA damage","downstream_event_id":185,"downstream_event":"Increase, Mutations"},{"relation":1902,"upstream_event_id":1635,"upstream_event":"Increase, DNA strand breaks","downstream_event_id":155,"downstream_event":"Inadequate DNA repair"},{"relation":1927,"upstream_event_id":1635,"upstream_event":"Increase, DNA strand breaks","downstream_event_id":185,"downstream_event":"Increase, Mutations"},{"relation":1904,"upstream_event_id":155,"upstream_event":"Inadequate DNA repair","downstream_event_id":185,"downstream_event":"Increase, Mutations"},{"relation":1903,"upstream_event_id":155,"upstream_event":"Inadequate DNA repair","downstream_event_id":1636,"downstream_event":"Increase, Chromosomal aberrations"},{"relation":1935,"upstream_event_id":1635,"upstream_event":"Increase, DNA strand breaks","downstream_event_id":1636,"downstream_event":"Increase, Chromosomal aberrations"}]}