{"id":301,"title":"Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis ","short_name":"Homocysteine, anterior-posterior axis ","created_at":"2019-06-14T08:41:37.000-04:00","updated_at":"2023-04-29T16:03:02.000-04:00","corresponding_author":{"id":859,"created_at":"2019-04-12T16:01:11.000-04:00","updated_at":"2026-07-03T03:42:16.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":493,"stressor_name":"Aminooxyacetic acid"},{"stressor_id":494,"stressor_name":"S-(4-Carboxybutyl)-D,L-homocysteine; 5-(3-Amino-3-carboxypropyl)sulfanyl-pentanoic acid"}],"aop_mies":[{"event_id":1657,"event":"Inhibition of cystathionine beta-synthase","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1661,"event":"Increased Homocysteine level ","event_type":"KeyEvent"},{"event_id":1665,"event":"Increased, Plasma HCY level","event_type":"KeyEvent"},{"event_id":1666,"event":"Induced, dysfunction of microcirculation","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1667,"event":"Impaired,anterior-posterior axis development","event_type":"AdverseOutcome"}],"relationships":[{"relation":1950,"upstream_event_id":1657,"upstream_event":"Inhibition of cystathionine beta-synthase","downstream_event_id":1661,"downstream_event":"Increased Homocysteine level "},{"relation":1961,"upstream_event_id":1661,"upstream_event":"Increased Homocysteine level ","downstream_event_id":1665,"downstream_event":"Increased, Plasma HCY level"},{"relation":1962,"upstream_event_id":1665,"upstream_event":"Increased, Plasma HCY level","downstream_event_id":1666,"downstream_event":"Induced, dysfunction of microcirculation"},{"relation":1963,"upstream_event_id":1666,"upstream_event":"Induced, dysfunction of microcirculation","downstream_event_id":1667,"downstream_event":"Impaired,anterior-posterior axis development"}]}