{"id":315,"title":"Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response","short_name":"Immune dysfunction induced by JAK3 inhibition","created_at":"2020-01-05T17:55:25.000-05:00","updated_at":"2025-04-16T22:00:16.000-04:00","corresponding_author":{"id":1279,"created_at":"2020-01-07T18:48:33.000-05:00","updated_at":"2025-04-16T21:50:29.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":585,"stressor_name":"PF-06651600 (CAS No：1792180-81-4), "},{"stressor_id":586,"stressor_name":"RB1"}],"aop_mies":[{"event_id":1715,"event":"Inhibition of JAK3","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1716,"event":"Blockade of STAT5 phosphorylation","event_type":"KeyEvent"},{"event_id":1717,"event":"Suppression of STAT5 binding to cytokine gene promoters","event_type":"KeyEvent"},{"event_id":1718,"event":"Suppression of IL-4 production","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1719,"event":"Impairment of T-cell dependent antibody response","event_type":"AdverseOutcome"}],"relationships":[{"relation":2051,"upstream_event_id":1715,"upstream_event":"Inhibition of JAK3","downstream_event_id":1716,"downstream_event":"Blockade of STAT5 phosphorylation"},{"relation":2052,"upstream_event_id":1716,"upstream_event":"Blockade of STAT5 phosphorylation","downstream_event_id":1717,"downstream_event":"Suppression of STAT5 binding to cytokine gene promoters"},{"relation":2053,"upstream_event_id":1717,"upstream_event":"Suppression of STAT5 binding to cytokine gene promoters","downstream_event_id":1718,"downstream_event":"Suppression of IL-4 production"},{"relation":2054,"upstream_event_id":1718,"upstream_event":"Suppression of IL-4 production","downstream_event_id":1719,"downstream_event":"Impairment of T-cell dependent antibody response"}]}