{"id":32,"title":"Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors","short_name":"Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-04-29T16:02:55.000-04:00","aop_stressors":[],"aop_mies":[],"aop_kes":[{"event_id":77,"event":"Production, Critical Metabolites (CGA 330050 and CGA 265307)","event_type":"KeyEvent"},{"event_id":164,"event":"Induction, Liver “Dysfunctional” Changes by CGA 330050","event_type":"KeyEvent"},{"event_id":147,"event":"Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307","event_type":"KeyEvent"},{"event_id":270,"event":"Induction, Sustained Hepatotoxicity","event_type":"KeyEvent"},{"event_id":269,"event":"Induction, Sustained Cell Proliferation","event_type":"KeyEvent"},{"event_id":347,"event":"Formation, Liver tumor","event_type":"KeyEvent"}],"aop_aos":[],"relationships":[{"relation":68,"upstream_event_id":77,"upstream_event":"Production, Critical Metabolites (CGA 330050 and CGA 265307)","downstream_event_id":164,"downstream_event":"Induction, Liver “Dysfunctional” Changes by CGA 330050"},{"relation":69,"upstream_event_id":164,"upstream_event":"Induction, Liver “Dysfunctional” Changes by CGA 330050","downstream_event_id":147,"downstream_event":"Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307"},{"relation":70,"upstream_event_id":147,"upstream_event":"Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307","downstream_event_id":270,"downstream_event":"Induction, Sustained Hepatotoxicity"},{"relation":71,"upstream_event_id":270,"upstream_event":"Induction, Sustained Hepatotoxicity","downstream_event_id":269,"downstream_event":"Induction, Sustained Cell Proliferation"},{"relation":72,"upstream_event_id":269,"upstream_event":"Induction, Sustained Cell Proliferation","downstream_event_id":347,"downstream_event":"Formation, Liver tumor"}]}