{"id":323,"title":"PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone","short_name":"PPARa Agonism Impairs Fish Reproduction","created_at":"2020-04-09T10:47:50.000-04:00","updated_at":"2023-09-28T16:35:32.000-04:00","corresponding_author":{"id":3100,"created_at":"2021-02-08T16:04:45.000-05:00","updated_at":"2023-10-04T14:53:16.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":191,"stressor_name":"Clofibrate"},{"stressor_id":208,"stressor_name":"Gemfibrozil"},{"stressor_id":211,"stressor_name":"Fenofibrate"}],"aop_mies":[{"event_id":227,"event":"Activation, PPARα","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":807,"event":"Decreased, cholesterol","event_type":"KeyEvent"},{"event_id":1756,"event":"Decreased,  plasma 11-ketotestosterone level","event_type":"KeyEvent"},{"event_id":1758,"event":"Impaired, Spermatogenesis","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2147,"event":"Decreased, Viable Offspring","event_type":"AdverseOutcome"},{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[{"relation":2111,"upstream_event_id":227,"upstream_event":"Activation, PPARα","downstream_event_id":807,"downstream_event":"Decreased, cholesterol"},{"relation":2112,"upstream_event_id":807,"upstream_event":"Decreased, cholesterol","downstream_event_id":1756,"downstream_event":"Decreased,  plasma 11-ketotestosterone level"},{"relation":2113,"upstream_event_id":1756,"upstream_event":"Decreased,  plasma 11-ketotestosterone level","downstream_event_id":1758,"downstream_event":"Impaired, Spermatogenesis"},{"relation":3487,"upstream_event_id":1758,"upstream_event":"Impaired, Spermatogenesis","downstream_event_id":2147,"downstream_event":"Decreased, Viable Offspring"},{"relation":3488,"upstream_event_id":2147,"upstream_event":"Decreased, Viable Offspring","downstream_event_id":360,"downstream_event":"Decrease, Population growth rate"}]}