{"id":331,"title":"Excessive reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death","short_name":"ROS leading to growth inhibition via LPO and cell death","created_at":"2020-04-19T04:50:03.000-04:00","updated_at":"2025-08-21T09:07:19.000-04:00","corresponding_author":{"id":322,"created_at":"2016-06-30T07:13:47.000-04:00","updated_at":"2026-03-04T05:15:11.000-05:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":274,"stressor_name":"Ultraviolet B radiation"}],"aop_mies":[{"event_id":1115,"event":"Increase, Reactive oxygen species","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1392,"event":"Increase, Oxidative Stress ","event_type":"KeyEvent"},{"event_id":1445,"event":"Increase, Lipid peroxidation","event_type":"KeyEvent"},{"event_id":1446,"event":"Decrease, Coupling of oxidative phosphorylation","event_type":"KeyEvent"},{"event_id":1771,"event":"Decrease, Adenosine triphosphate pool","event_type":"KeyEvent"},{"event_id":55,"event":"Increase, Cell injury/death","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1521,"event":"Decrease, Growth","event_type":"AdverseOutcome"}],"relationships":[{"relation":4482,"upstream_event_id":1115,"upstream_event":"Increase, Reactive oxygen species","downstream_event_id":1392,"downstream_event":"Increase, Oxidative Stress "},{"relation":4483,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":1445,"downstream_event":"Increase, Lipid peroxidation"},{"relation":4484,"upstream_event_id":1445,"upstream_event":"Increase, Lipid peroxidation","downstream_event_id":1446,"downstream_event":"Decrease, Coupling of oxidative phosphorylation"},{"relation":4485,"upstream_event_id":1446,"upstream_event":"Decrease, Coupling of oxidative phosphorylation","downstream_event_id":1771,"downstream_event":"Decrease, Adenosine triphosphate pool"},{"relation":4486,"upstream_event_id":1771,"upstream_event":"Decrease, Adenosine triphosphate pool","downstream_event_id":55,"downstream_event":"Increase, Cell injury/death"},{"relation":4487,"upstream_event_id":55,"upstream_event":"Increase, Cell injury/death","downstream_event_id":1521,"downstream_event":"Decrease, Growth"}]}