{"id":345,"title":"Androgen receptor (AR) antagonism leading to decreased fertility in females","short_name":"AR antagonism leading to decreased fertility","created_at":"2020-05-19T16:32:18.000-04:00","updated_at":"2025-03-18T12:25:22.000-04:00","corresponding_author":{"id":918,"created_at":"2019-06-27T09:30:29.000-04:00","updated_at":"2026-02-04T07:42:28.000-05:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":137,"stressor_name":"Flutamide"}],"aop_mies":[{"event_id":26,"event":"Antagonism, Androgen receptor","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1614,"event":"Decrease, androgen receptor activation","event_type":"KeyEvent"},{"event_id":286,"event":"Altered, Transcription of genes by the androgen receptor","event_type":"KeyEvent"},{"event_id":1800,"event":"Granulosa cell proliferation of gonadotropin-independent follicles, Reduced","event_type":"KeyEvent"}],"aop_aos":[{"event_id":405,"event":"disrupted, ovarian cycle","event_type":"AdverseOutcome"},{"event_id":406,"event":"decreased, Fertility","event_type":"AdverseOutcome"}],"relationships":[{"relation":3828,"upstream_event_id":26,"upstream_event":"Antagonism, Androgen receptor","downstream_event_id":1614,"downstream_event":"Decrease, androgen receptor activation"},{"relation":3829,"upstream_event_id":1614,"upstream_event":"Decrease, androgen receptor activation","downstream_event_id":286,"downstream_event":"Altered, Transcription of genes by the androgen receptor"},{"relation":2499,"upstream_event_id":286,"upstream_event":"Altered, Transcription of genes by the androgen receptor","downstream_event_id":1800,"downstream_event":"Granulosa cell proliferation of gonadotropin-independent follicles, Reduced"},{"relation":3763,"upstream_event_id":1800,"upstream_event":"Granulosa cell proliferation of gonadotropin-independent follicles, Reduced","downstream_event_id":405,"downstream_event":"disrupted, ovarian cycle"},{"relation":3762,"upstream_event_id":405,"upstream_event":"disrupted, ovarian cycle","downstream_event_id":406,"downstream_event":"decreased, Fertility"}]}