{"id":347,"title":"Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis","short_name":"TLR4 activation, PPAR gamma activation and Pulmonary fibrosis","created_at":"2020-06-29T02:57:02.000-04:00","updated_at":"2023-04-29T16:03:03.000-04:00","corresponding_author":{"id":286,"created_at":"2015-09-07T04:17:35.000-04:00","updated_at":"2021-04-13T09:42:59.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":1792,"event":"Toll-like receptor 4 activation","event_type":"MolecularInitiatingEvent"},{"event_id":1270,"event":"Inactivation of PPARγ","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1292,"event":"Activation, JNK","event_type":"KeyEvent"},{"event_id":1793,"event":"Activator protein 1 activation","event_type":"KeyEvent"},{"event_id":1794,"event":"Pin-1 activation","event_type":"KeyEvent"},{"event_id":1795,"event":"Latent Transforming growth Factor beta expression","event_type":"KeyEvent"},{"event_id":1283,"event":"Activation, TGF-beta pathway","event_type":"KeyEvent"},{"event_id":1457,"event":"Epithelial Mesenchymal Transition","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1458,"event":"Pulmonary fibrosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":2232,"upstream_event_id":1792,"upstream_event":"Toll-like receptor 4 activation","downstream_event_id":1292,"downstream_event":"Activation, JNK"},{"relation":2469,"upstream_event_id":1292,"upstream_event":"Activation, JNK","downstream_event_id":1793,"downstream_event":"Activator protein 1 activation"},{"relation":2234,"upstream_event_id":1292,"upstream_event":"Activation, JNK","downstream_event_id":1794,"downstream_event":"Pin-1 activation"},{"relation":2235,"upstream_event_id":1794,"upstream_event":"Pin-1 activation","downstream_event_id":1795,"downstream_event":"Latent Transforming growth Factor beta expression"},{"relation":2236,"upstream_event_id":1795,"upstream_event":"Latent Transforming growth Factor beta expression","downstream_event_id":1283,"downstream_event":"Activation, TGF-beta pathway"},{"relation":2237,"upstream_event_id":1283,"upstream_event":"Activation, TGF-beta pathway","downstream_event_id":1457,"downstream_event":"Epithelial Mesenchymal Transition"},{"relation":2238,"upstream_event_id":1457,"upstream_event":"Epithelial Mesenchymal Transition","downstream_event_id":1458,"downstream_event":"Pulmonary fibrosis"},{"relation":2240,"upstream_event_id":1270,"upstream_event":"Inactivation of PPARγ","downstream_event_id":1283,"downstream_event":"Activation, TGF-beta pathway"},{"relation":2241,"upstream_event_id":1793,"upstream_event":"Activator protein 1 activation","downstream_event_id":1795,"downstream_event":"Latent Transforming growth Factor beta expression"}]}