85-01-8 YNPNZTXNASCQKK-UHFFFAOYSA-N YNPNZTXNASCQKK-UHFFFAOYSA-N Phenanthrene [3]Helicene fenantreno, puro NSC 26256 Phenanthren Ravatite DTXSID6024254 GO:0016020 GO membrane GO:0005886 GO plasma membrane 1 WIKI increased 4 WIKI abnormal Phenanthrene 2016-11-29T18:42:22 2016-11-29T18:42:22 Accumulation, Biological membranes Cellular CL:0000255 CL eukaryotic cell AOPWiki 2016-11-29T18:41:22 2017-09-16T10:14:55 Disruption, Membrane integrity Cellular CL:0000255 CL eukaryotic cell AOPWiki 2016-11-29T18:41:23 2017-09-16T10:14:55 Narcosis leading to respiratory failure Dries Knapen BY-SA Under Development 1.2 1.0 <p><em>Consider the following criteria (may include references to KE Relationship pages): 1. concordance of dose-response relationships; 2. temporal concordance among the key events and adverse effect; 3. strength, consistency, and specificity of association of adverse effect and initiating event; 4. biological plausibility, coherence, and consistency of the experimental evidence; 5. alternative mechanisms that logically present themselves and the extent to which they may distract from the postulated AOP. It should be noted that alternative mechanisms of action, if supported, require a separate AOP; 6. uncertainties, inconsistencies and data gaps. </em></p> AOPWiki 2016-11-29T18:41:16 2023-04-29T16:02:55