{"id":363,"title":"Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure","short_name":"TPOi retinal layer structure","created_at":"2020-12-09T07:45:26.000-05:00","updated_at":"2025-07-01T11:43:40.000-04:00","corresponding_author":{"id":207,"created_at":"2014-01-14T10:54:37.000-05:00","updated_at":"2025-12-11T12:28:38.000-05:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":48,"stressor_name":"Propylthiouracil"},{"stressor_id":37,"stressor_name":"Methimazole"}],"aop_mies":[{"event_id":279,"event":"Thyroperoxidase, Inhibition","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":277,"event":"Thyroid hormone synthesis, Decreased","event_type":"KeyEvent"},{"event_id":281,"event":" Thyroxine (T4) in serum, Decreased","event_type":"KeyEvent"},{"event_id":1003,"event":"Decreased, Triiodothyronine (T3)","event_type":"KeyEvent"},{"event_id":1877,"event":"Altered, retinal layer structure","event_type":"KeyEvent"},{"event_id":1643,"event":"Altered, Visual function","event_type":"KeyEvent"}],"aop_aos":[{"event_id":351,"event":"Increased Mortality","event_type":"AdverseOutcome"},{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[{"relation":2464,"upstream_event_id":279,"upstream_event":"Thyroperoxidase, Inhibition","downstream_event_id":277,"downstream_event":"Thyroid hormone synthesis, Decreased"},{"relation":2699,"upstream_event_id":279,"upstream_event":"Thyroperoxidase, Inhibition","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"},{"relation":2465,"upstream_event_id":277,"upstream_event":"Thyroid hormone synthesis, Decreased","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"},{"relation":2466,"upstream_event_id":281,"upstream_event":" Thyroxine (T4) in serum, Decreased","downstream_event_id":1003,"downstream_event":"Decreased, Triiodothyronine (T3)"},{"relation":2656,"upstream_event_id":1003,"upstream_event":"Decreased, Triiodothyronine (T3)","downstream_event_id":1877,"downstream_event":"Altered, retinal layer structure"},{"relation":2914,"upstream_event_id":1877,"upstream_event":"Altered, retinal layer structure","downstream_event_id":1643,"downstream_event":"Altered, Visual function"},{"relation":2915,"upstream_event_id":1643,"upstream_event":"Altered, Visual function","downstream_event_id":351,"downstream_event":"Increased Mortality"},{"relation":2467,"upstream_event_id":351,"upstream_event":"Increased Mortality","downstream_event_id":360,"downstream_event":"Decrease, Population growth rate"}]}