{"id":367,"title":"Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis","short_name":"TH displacement from serum TBG leading to altered amphibian metamorphosis","created_at":"2020-12-09T15:22:16.000-05:00","updated_at":"2023-04-29T16:03:03.000-04:00","corresponding_author":{"id":142,"created_at":"2015-07-24T10:53:28.000-04:00","updated_at":"2021-07-13T15:26:42.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":1831,"event":"Binding, Thyroid binding globulin in serum","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1830,"event":"Displacement, Serum thyroxine (T4) from carrier protein","event_type":"KeyEvent"},{"event_id":959,"event":"Increased, Free serum thyroxine (T4)","event_type":"KeyEvent"},{"event_id":1158,"event":"Increased, Hepatic thyroid hormone uptake/transport","event_type":"KeyEvent"},{"event_id":961,"event":"Increased, Clearance of thyroxine from serum","event_type":"KeyEvent"},{"event_id":281,"event":" Thyroxine (T4) in serum, Decreased","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1101,"event":"Altered, Amphibian metamorphosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":2825,"upstream_event_id":1158,"upstream_event":"Increased, Hepatic thyroid hormone uptake/transport","downstream_event_id":961,"downstream_event":"Increased, Clearance of thyroxine from serum"},{"relation":2457,"upstream_event_id":1831,"upstream_event":"Binding, Thyroid binding globulin in serum","downstream_event_id":1830,"downstream_event":"Displacement, Serum thyroxine (T4) from carrier protein"},{"relation":2458,"upstream_event_id":1830,"upstream_event":"Displacement, Serum thyroxine (T4) from carrier protein","downstream_event_id":959,"downstream_event":"Increased, Free serum thyroxine (T4)"},{"relation":2463,"upstream_event_id":281,"upstream_event":" Thyroxine (T4) in serum, Decreased","downstream_event_id":1101,"downstream_event":"Altered, Amphibian metamorphosis"},{"relation":2459,"upstream_event_id":959,"upstream_event":"Increased, Free serum thyroxine (T4)","downstream_event_id":1158,"downstream_event":"Increased, Hepatic thyroid hormone uptake/transport"},{"relation":2460,"upstream_event_id":1158,"upstream_event":"Increased, Hepatic thyroid hormone uptake/transport","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"},{"relation":2824,"upstream_event_id":961,"upstream_event":"Increased, Clearance of thyroxine from serum","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"}]}