{"id":37,"title":"PPARα activation leading to hepatocellular adenomas and carcinomas in rodents","short_name":"PPARalpha-dependent liver tumors in rodents","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-04-29T16:02:55.000-04:00","corresponding_author":{"id":74,"created_at":"2014-02-03T11:10:50.000-05:00","updated_at":"2024-03-04T17:28:20.000-05:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":205,"stressor_name":"pirinixic acid"},{"stressor_id":191,"stressor_name":"Clofibrate"},{"stressor_id":11,"stressor_name":"Bis(2-ethylhexyl) phthalate"},{"stressor_id":206,"stressor_name":"Nafenopin"},{"stressor_id":207,"stressor_name":"ciprofibrate"},{"stressor_id":208,"stressor_name":"Gemfibrozil"},{"stressor_id":175,"stressor_name":"PERFLUOROOCTANOIC ACID"},{"stressor_id":210,"stressor_name":"Bezafibrate"},{"stressor_id":211,"stressor_name":"Fenofibrate"}],"aop_mies":[{"event_id":227,"event":"Activation, PPARα","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1170,"event":"Increase, Phenotypic enzyme activity","event_type":"KeyEvent"},{"event_id":716,"event":"Increase, cell proliferation (hepatocytes)","event_type":"KeyEvent"},{"event_id":1171,"event":"Increase, Clonal Expansion of Altered Hepatic Foci","event_type":"KeyEvent"}],"aop_aos":[{"event_id":719,"event":"Increase, hepatocellular adenomas and carcinomas","event_type":"AdverseOutcome"}],"relationships":[{"relation":2471,"upstream_event_id":227,"upstream_event":"Activation, PPARα","downstream_event_id":1170,"downstream_event":"Increase, Phenotypic enzyme activity"},{"relation":923,"upstream_event_id":1170,"upstream_event":"Increase, Phenotypic enzyme activity","downstream_event_id":716,"downstream_event":"Increase, cell proliferation (hepatocytes)"},{"relation":931,"upstream_event_id":716,"upstream_event":"Increase, cell proliferation (hepatocytes)","downstream_event_id":1171,"downstream_event":"Increase, Clonal Expansion of Altered Hepatic Foci"},{"relation":925,"upstream_event_id":1171,"upstream_event":"Increase, Clonal Expansion of Altered Hepatic Foci","downstream_event_id":719,"downstream_event":"Increase, hepatocellular adenomas and carcinomas"},{"relation":2470,"upstream_event_id":227,"upstream_event":"Activation, PPARα","downstream_event_id":716,"downstream_event":"Increase, cell proliferation (hepatocytes)"},{"relation":2472,"upstream_event_id":227,"upstream_event":"Activation, PPARα","downstream_event_id":719,"downstream_event":"Increase, hepatocellular adenomas and carcinomas"},{"relation":2473,"upstream_event_id":716,"upstream_event":"Increase, cell proliferation (hepatocytes)","downstream_event_id":719,"downstream_event":"Increase, hepatocellular adenomas and carcinomas"}]}