{"id":383,"title":"Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis","short_name":"ACE2 inhibition, liver fibrosis","created_at":"2021-03-30T13:45:49.000-04:00","updated_at":"2023-04-29T16:03:04.000-04:00","corresponding_author":{"id":859,"created_at":"2019-04-12T16:01:11.000-04:00","updated_at":"2026-01-19T09:09:00.000-05:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":1740,"event":"Induced dysregulation of ACE2 ","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1743,"event":"Increase plasma Ang II","event_type":"KeyEvent"},{"event_id":1852,"event":"Increased Ang II type 1 receptor (AT1R)","event_type":"KeyEvent"},{"event_id":1115,"event":"Increase, Reactive oxygen species","event_type":"KeyEvent"},{"event_id":1501,"event":"Increase, Extracellular matrix deposition","event_type":"KeyEvent"}],"aop_aos":[{"event_id":344,"event":"Increase, Liver fibrosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":2579,"upstream_event_id":1852,"upstream_event":"Increased Ang II type 1 receptor (AT1R)","downstream_event_id":1115,"downstream_event":"Increase, Reactive oxygen species"},{"relation":2763,"upstream_event_id":1743,"upstream_event":"Increase plasma Ang II","downstream_event_id":1852,"downstream_event":"Increased Ang II type 1 receptor (AT1R)"},{"relation":2580,"upstream_event_id":1115,"upstream_event":"Increase, Reactive oxygen species","downstream_event_id":1501,"downstream_event":"Increase, Extracellular matrix deposition"},{"relation":2581,"upstream_event_id":1501,"upstream_event":"Increase, Extracellular matrix deposition","downstream_event_id":344,"downstream_event":"Increase, Liver fibrosis"},{"relation":2762,"upstream_event_id":1740,"upstream_event":"Induced dysregulation of ACE2 ","downstream_event_id":1743,"downstream_event":"Increase plasma Ang II"}]}