{"id":4,"title":"Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1","short_name":"EcR agonism leading to mortality via suppression of Ftz-f1","created_at":"2016-11-29T18:41:15.000-05:00","updated_at":"2025-10-02T04:18:29.000-04:00","corresponding_author":{"id":184,"created_at":"2013-08-12T09:37:11.000-04:00","updated_at":"2026-06-05T10:30:10.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":164,"stressor_name":"Tebufenozide"},{"stressor_id":241,"stressor_name":"20-hydroxyecdysone"},{"stressor_id":242,"stressor_name":"Ponasterone A"},{"stressor_id":238,"stressor_name":"Methoxyfenozide"},{"stressor_id":239,"stressor_name":"Halofenozide"},{"stressor_id":243,"stressor_name":"Chromafenozide"},{"stressor_id":244,"stressor_name":"Cyasterone"},{"stressor_id":245,"stressor_name":"Makisterone A"},{"stressor_id":246,"stressor_name":"Inokosterone"},{"stressor_id":247,"stressor_name":"Ecdysone"},{"stressor_id":248,"stressor_name":"RH-5849"}],"aop_mies":[{"event_id":103,"event":"Increase, Ecdysone receptor hyperactivation","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1264,"event":"Increase, Nuclear receptor E75b gene expression","event_type":"KeyEvent"},{"event_id":1265,"event":"Decrease, Fushi tarazu factor-1 gene expression","event_type":"KeyEvent"},{"event_id":988,"event":"Decrease, Circulating ecdysis triggering hormone","event_type":"KeyEvent"},{"event_id":1266,"event":"Decrease, Circulating crustacean cardioactive peptide","event_type":"KeyEvent"},{"event_id":1267,"event":"Decrease, Ecdysis motor program activity","event_type":"KeyEvent"},{"event_id":993,"event":"Decrease, Abdominal muscle contraction","event_type":"KeyEvent"}],"aop_aos":[{"event_id":990,"event":"Increase, Incomplete ecdysis","event_type":"AdverseOutcome"},{"event_id":350,"event":"Increase, Mortality","event_type":"AdverseOutcome"}],"relationships":[{"relation":1121,"upstream_event_id":103,"upstream_event":"Increase, Ecdysone receptor hyperactivation","downstream_event_id":1264,"downstream_event":"Increase, Nuclear receptor E75b gene expression"},{"relation":1122,"upstream_event_id":1264,"upstream_event":"Increase, Nuclear receptor E75b gene expression","downstream_event_id":1265,"downstream_event":"Decrease, Fushi tarazu factor-1 gene expression"},{"relation":1123,"upstream_event_id":1265,"upstream_event":"Decrease, Fushi tarazu factor-1 gene expression","downstream_event_id":988,"downstream_event":"Decrease, Circulating ecdysis triggering hormone"},{"relation":1124,"upstream_event_id":988,"upstream_event":"Decrease, Circulating ecdysis triggering hormone","downstream_event_id":1266,"downstream_event":"Decrease, Circulating crustacean cardioactive peptide"},{"relation":1125,"upstream_event_id":1266,"upstream_event":"Decrease, Circulating crustacean cardioactive peptide","downstream_event_id":1267,"downstream_event":"Decrease, Ecdysis motor program activity"},{"relation":4575,"upstream_event_id":1267,"upstream_event":"Decrease, Ecdysis motor program activity","downstream_event_id":993,"downstream_event":"Decrease, Abdominal muscle contraction"},{"relation":4576,"upstream_event_id":993,"upstream_event":"Decrease, Abdominal muscle contraction","downstream_event_id":990,"downstream_event":"Increase, Incomplete ecdysis"},{"relation":4577,"upstream_event_id":990,"upstream_event":"Increase, Incomplete ecdysis","downstream_event_id":350,"downstream_event":"Increase, Mortality"}]}