{"id":400,"title":"Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility","short_name":"Inhibition CYP26B1 in fetal testis leads to reduced fertility","created_at":"2021-05-29T12:26:47.000-04:00","updated_at":"2026-05-01T07:46:27.000-04:00","corresponding_author":{"id":918,"created_at":"2019-06-27T09:30:29.000-04:00","updated_at":"2026-04-15T03:42:44.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":1887,"event":"Inhibition of CYP26B1 activity","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1888,"event":"Increased (ectopic) all-trans retinoic acid concentration","event_type":"KeyEvent"},{"event_id":2420,"event":"Increased, Retinoic Acid Receptor Activation","event_type":"KeyEvent"},{"event_id":1889,"event":"Increased premature meiotic initiation in fetal male germ cells","event_type":"KeyEvent"},{"event_id":1890,"event":"Decrease (loss of) fetal male germ cells","event_type":"KeyEvent"},{"event_id":1757,"event":"Reduce, Sperm count","event_type":"KeyEvent"}],"aop_aos":[{"event_id":406,"event":"decreased, Fertility","event_type":"AdverseOutcome"}],"relationships":[{"relation":4937,"upstream_event_id":1887,"upstream_event":"Inhibition of CYP26B1 activity","downstream_event_id":1888,"downstream_event":"Increased (ectopic) all-trans retinoic acid concentration"},{"relation":4957,"upstream_event_id":1888,"upstream_event":"Increased (ectopic) all-trans retinoic acid concentration","downstream_event_id":1889,"downstream_event":"Increased premature meiotic initiation in fetal male germ cells"},{"relation":4938,"upstream_event_id":1888,"upstream_event":"Increased (ectopic) all-trans retinoic acid concentration","downstream_event_id":2420,"downstream_event":"Increased, Retinoic Acid Receptor Activation"},{"relation":4939,"upstream_event_id":2420,"upstream_event":"Increased, Retinoic Acid Receptor Activation","downstream_event_id":1889,"downstream_event":"Increased premature meiotic initiation in fetal male germ cells"},{"relation":4940,"upstream_event_id":1889,"upstream_event":"Increased premature meiotic initiation in fetal male germ cells","downstream_event_id":1890,"downstream_event":"Decrease (loss of) fetal male germ cells"},{"relation":4941,"upstream_event_id":1890,"upstream_event":"Decrease (loss of) fetal male germ cells","downstream_event_id":1757,"downstream_event":"Reduce, Sperm count"},{"relation":4942,"upstream_event_id":1757,"upstream_event":"Reduce, Sperm count","downstream_event_id":406,"downstream_event":"decreased, Fertility"}]}