{"id":416,"title":"Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway","short_name":"AHR activation leading to lung cancer via IL-6 tox path","created_at":"2021-08-14T01:50:20.000-04:00","updated_at":"2023-04-29T16:03:05.000-04:00","corresponding_author":{"id":5473,"created_at":"2021-07-29T06:52:04.000-04:00","updated_at":"2026-04-23T02:56:55.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":18,"event":"Activation, AhR","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1921,"event":"Altered gene expression, NF-kB dependent Interleukin-6 pathway","event_type":"KeyEvent"},{"event_id":1933,"event":"Increased, Interleukin-6 production","event_type":"KeyEvent"},{"event_id":1115,"event":"Increase, Reactive oxygen species","event_type":"KeyEvent"},{"event_id":1669,"event":"Increased, DNA damage and mutation","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1670,"event":"Lung cancer","event_type":"AdverseOutcome"}],"relationships":[]}