{"id":428,"title":"Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis ","short_name":"ACE2 dysregulation leads to gut dysbiosis","created_at":"2021-10-19T13:52:33.000-04:00","updated_at":"2023-04-29T16:03:05.000-04:00","corresponding_author":{"id":2471,"created_at":"2020-12-02T07:47:44.000-05:00","updated_at":"2024-11-25T10:32:54.000-05:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":1739,"event":"Binding to ACE2","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1854,"event":"Dysregulation, ACE2 expression and activity","event_type":"KeyEvent"},{"event_id":1954,"event":"Gut microbiota, alteration","event_type":"KeyEvent"}],"aop_aos":[],"relationships":[{"relation":2870,"upstream_event_id":1739,"upstream_event":"Binding to ACE2","downstream_event_id":1854,"downstream_event":"Dysregulation, ACE2 expression and activity"},{"relation":2897,"upstream_event_id":1854,"upstream_event":"Dysregulation, ACE2 expression and activity","downstream_event_id":1954,"downstream_event":"Gut microbiota, alteration"}]}