{"id":436,"title":"Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries","short_name":"RALDH2 and cardiovascular developmental defects","created_at":"2022-01-27T11:16:35.000-05:00","updated_at":"2023-04-29T16:03:05.000-04:00","corresponding_author":{"id":8388,"created_at":"2022-01-07T10:11:09.000-05:00","updated_at":"2022-02-15T10:27:39.000-05:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":728,"stressor_name":"4-diethylaminobenzaldehyde (DEAB)"},{"stressor_id":310,"stressor_name":"Disulfiram"},{"stressor_id":729,"stressor_name":"WIN18466"},{"stressor_id":465,"stressor_name":"nitrofen"},{"stressor_id":360,"stressor_name":"Ethanol"},{"stressor_id":731,"stressor_name":"All-trans retionic acid"},{"stressor_id":467,"stressor_name":"Bisdiamine"},{"stressor_id":732,"stressor_name":"Vitamin A"},{"stressor_id":726,"stressor_name":"BMS-89453"}],"aop_mies":[{"event_id":1880,"event":"Decreased, ALDH1A (RALDH) enzyme activity","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1881,"event":"Decreased, all-trans retinoic acid (atRA) concentration","event_type":"KeyEvent"},{"event_id":1682,"event":"Disruption, Progenitor cells of second heart field","event_type":"KeyEvent"},{"event_id":1557,"event":"Neural crest cell migration, reduced","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1970,"event":"transposition of the great arteries","event_type":"AdverseOutcome"}],"relationships":[{"relation":2944,"upstream_event_id":1880,"upstream_event":"Decreased, ALDH1A (RALDH) enzyme activity","downstream_event_id":1881,"downstream_event":"Decreased, all-trans retinoic acid (atRA) concentration"},{"relation":2945,"upstream_event_id":1881,"upstream_event":"Decreased, all-trans retinoic acid (atRA) concentration","downstream_event_id":1682,"downstream_event":"Disruption, Progenitor cells of second heart field"},{"relation":2946,"upstream_event_id":1682,"upstream_event":"Disruption, Progenitor cells of second heart field","downstream_event_id":1557,"downstream_event":"Neural crest cell migration, reduced"},{"relation":2947,"upstream_event_id":1557,"upstream_event":"Neural crest cell migration, reduced","downstream_event_id":1970,"downstream_event":"transposition of the great arteries"}]}