{"id":445,"title":"Estrogen Receptor Alpha Agonism leads to Impaired Reproduction","short_name":"ERα Agonism leads to Impaired Reproduction","created_at":"2022-04-05T00:44:11.000-04:00","updated_at":"2023-04-29T16:03:06.000-04:00","corresponding_author":{"id":2944,"created_at":"2021-01-25T13:11:17.000-05:00","updated_at":"2022-08-15T02:42:13.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":1065,"event":"Activation, estrogen receptor alpha","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1985,"event":"Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)","event_type":"KeyEvent"},{"event_id":1986,"event":"Decreased, Gonadotropins","event_type":"KeyEvent"},{"event_id":1987,"event":"Decreased, Androgen and Progestin ","event_type":"KeyEvent"},{"event_id":1988,"event":"Decreased, Maturation Inducing Steroid Surge by Granulosa cells","event_type":"KeyEvent"},{"event_id":1989,"event":"Impaired, Oocyte maturation and ovulation","event_type":"KeyEvent"},{"event_id":1990,"event":"Increased, Oocyte Atresia","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1991,"event":"Impaired, Reproduction","event_type":"AdverseOutcome"}],"relationships":[{"relation":3101,"upstream_event_id":1065,"upstream_event":"Activation, estrogen receptor alpha","downstream_event_id":1985,"downstream_event":"Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)"},{"relation":3055,"upstream_event_id":1985,"upstream_event":"Increased Kisspeptin levels in anteroventral periventricular nucleus (AVPV)","downstream_event_id":1986,"downstream_event":"Decreased, Gonadotropins"},{"relation":3102,"upstream_event_id":1065,"upstream_event":"Activation, estrogen receptor alpha","downstream_event_id":1986,"downstream_event":"Decreased, Gonadotropins"},{"relation":3057,"upstream_event_id":1986,"upstream_event":"Decreased, Gonadotropins","downstream_event_id":1987,"downstream_event":"Decreased, Androgen and Progestin "},{"relation":3185,"upstream_event_id":1065,"upstream_event":"Activation, estrogen receptor alpha","downstream_event_id":1991,"downstream_event":"Impaired, Reproduction"},{"relation":3058,"upstream_event_id":1987,"upstream_event":"Decreased, Androgen and Progestin ","downstream_event_id":1988,"downstream_event":"Decreased, Maturation Inducing Steroid Surge by Granulosa cells"},{"relation":3059,"upstream_event_id":1988,"upstream_event":"Decreased, Maturation Inducing Steroid Surge by Granulosa cells","downstream_event_id":1989,"downstream_event":"Impaired, Oocyte maturation and ovulation"},{"relation":3060,"upstream_event_id":1989,"upstream_event":"Impaired, Oocyte maturation and ovulation","downstream_event_id":1990,"downstream_event":"Increased, Oocyte Atresia"},{"relation":3061,"upstream_event_id":1990,"upstream_event":"Increased, Oocyte Atresia","downstream_event_id":1991,"downstream_event":"Impaired, Reproduction"}]}