{"id":455,"title":"Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development","short_name":"Ahr mediated early stage mortality via craniofacial malformations","created_at":"2022-06-28T13:22:12.000-04:00","updated_at":"2025-07-01T10:22:43.000-04:00","corresponding_author":{"id":9786,"created_at":"2022-04-15T12:24:36.000-04:00","updated_at":"2024-09-25T11:30:18.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":249,"stressor_name":"2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)"}],"aop_mies":[{"event_id":18,"event":"Activation, AhR","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":944,"event":"dimerization, AHR/ARNT","event_type":"KeyEvent"},{"event_id":2021,"event":"Increase, slincR expression","event_type":"KeyEvent"},{"event_id":2020,"event":"Decrease, sox9 expression","event_type":"KeyEvent"}],"aop_aos":[{"event_id":947,"event":"Increase, Early Life Stage Mortality","event_type":"AdverseOutcome"},{"event_id":1559,"event":"Facial cartilage structures are reduced in size and morphologically distorted","event_type":"AdverseOutcome"}],"relationships":[{"relation":3124,"upstream_event_id":18,"upstream_event":"Activation, AhR","downstream_event_id":944,"downstream_event":"dimerization, AHR/ARNT"},{"relation":3126,"upstream_event_id":944,"upstream_event":"dimerization, AHR/ARNT","downstream_event_id":2021,"downstream_event":"Increase, slincR expression"},{"relation":3131,"upstream_event_id":18,"upstream_event":"Activation, AhR","downstream_event_id":2020,"downstream_event":"Decrease, sox9 expression"},{"relation":3127,"upstream_event_id":2021,"upstream_event":"Increase, slincR expression","downstream_event_id":2020,"downstream_event":"Decrease, sox9 expression"},{"relation":3128,"upstream_event_id":2020,"upstream_event":"Decrease, sox9 expression","downstream_event_id":1559,"downstream_event":"Facial cartilage structures are reduced in size and morphologically distorted"},{"relation":3129,"upstream_event_id":1559,"upstream_event":"Facial cartilage structures are reduced in size and morphologically distorted","downstream_event_id":947,"downstream_event":"Increase, Early Life Stage Mortality"},{"relation":3134,"upstream_event_id":2021,"upstream_event":"Increase, slincR expression","downstream_event_id":1559,"downstream_event":"Facial cartilage structures are reduced in size and morphologically distorted"},{"relation":3227,"upstream_event_id":18,"upstream_event":"Activation, AhR","downstream_event_id":947,"downstream_event":"Increase, Early Life Stage Mortality"},{"relation":3231,"upstream_event_id":18,"upstream_event":"Activation, AhR","downstream_event_id":1559,"downstream_event":"Facial cartilage structures are reduced in size and morphologically distorted"}]}