{"id":462,"title":"Activation of reactive oxygen species leading the atherosclerosis","short_name":"Activation of ROS leading the atherosclerosis","created_at":"2022-07-19T03:38:23.000-04:00","updated_at":"2024-11-25T19:23:36.000-05:00","corresponding_author":{"id":9215,"created_at":"2022-03-01T01:45:21.000-05:00","updated_at":"2024-12-04T06:17:51.000-05:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":303,"stressor_name":"Reactive oxygen species"}],"aop_mies":[{"event_id":1115,"event":"Increase, Reactive oxygen species","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1392,"event":"Increase, Oxidative Stress ","event_type":"KeyEvent"},{"event_id":2068,"event":"Increase, Endothelial Dysfunction","event_type":"KeyEvent"},{"event_id":901,"event":"Infiltration, Inflammatory cells","event_type":"KeyEvent"},{"event_id":1198,"event":"Activation, Macrophages","event_type":"KeyEvent"},{"event_id":467,"event":"Increased, LDL uptake","event_type":"KeyEvent"},{"event_id":1442,"event":"Foam cell formation","event_type":"KeyEvent"}],"aop_aos":[],"relationships":[{"relation":4186,"upstream_event_id":1115,"upstream_event":"Increase, Reactive oxygen species","downstream_event_id":1392,"downstream_event":"Increase, Oxidative Stress "},{"relation":4187,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":2068,"downstream_event":"Increase, Endothelial Dysfunction"},{"relation":4188,"upstream_event_id":2068,"upstream_event":"Increase, Endothelial Dysfunction","downstream_event_id":901,"downstream_event":"Infiltration, Inflammatory cells"},{"relation":4189,"upstream_event_id":901,"upstream_event":"Infiltration, Inflammatory cells","downstream_event_id":1198,"downstream_event":"Activation, Macrophages"},{"relation":4191,"upstream_event_id":1198,"upstream_event":"Activation, Macrophages","downstream_event_id":1442,"downstream_event":"Foam cell formation"},{"relation":4192,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":467,"downstream_event":"Increased, LDL uptake"},{"relation":4193,"upstream_event_id":467,"upstream_event":"Increased, LDL uptake","downstream_event_id":1442,"downstream_event":"Foam cell formation"}]}