{"id":467,"title":"Knickkopf leading to mortality","short_name":"Knickkopf leading to mortality","created_at":"2022-08-28T21:06:53.000-04:00","updated_at":"2024-10-07T19:04:31.000-04:00","corresponding_author":{"id":9148,"created_at":"2022-02-21T20:18:20.000-05:00","updated_at":"2026-06-16T21:54:18.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":2058,"event":"Decrease, 20-hydroxyecdysone","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2059,"event":"Decrease, knickkopf gene","event_type":"KeyEvent"},{"event_id":2060,"event":"Decrease, Chitin laminar organization","event_type":"KeyEvent"},{"event_id":2061,"event":"Decrease, Prevent chitin degradation by chitinases","event_type":"KeyEvent"},{"event_id":2062,"event":"Weak, Procuticle protection","event_type":"KeyEvent"},{"event_id":2063,"event":"Decrease, New cuticle secretion","event_type":"KeyEvent"},{"event_id":990,"event":"Increase, Incomplete ecdysis","event_type":"KeyEvent"},{"event_id":2050,"event":"Increase, developmental abnormalities","event_type":"KeyEvent"},{"event_id":350,"event":"Increase, Mortality","event_type":"KeyEvent"}],"aop_aos":[],"relationships":[{"relation":3208,"upstream_event_id":2058,"upstream_event":"Decrease, 20-hydroxyecdysone","downstream_event_id":2059,"downstream_event":"Decrease, knickkopf gene"},{"relation":3209,"upstream_event_id":2059,"upstream_event":"Decrease, knickkopf gene","downstream_event_id":2060,"downstream_event":"Decrease, Chitin laminar organization"},{"relation":3210,"upstream_event_id":2059,"upstream_event":"Decrease, knickkopf gene","downstream_event_id":2061,"downstream_event":"Decrease, Prevent chitin degradation by chitinases"},{"relation":3211,"upstream_event_id":2060,"upstream_event":"Decrease, Chitin laminar organization","downstream_event_id":2062,"downstream_event":"Weak, Procuticle protection"},{"relation":3212,"upstream_event_id":2061,"upstream_event":"Decrease, Prevent chitin degradation by chitinases","downstream_event_id":2062,"downstream_event":"Weak, Procuticle protection"},{"relation":3213,"upstream_event_id":2062,"upstream_event":"Weak, Procuticle protection","downstream_event_id":2063,"downstream_event":"Decrease, New cuticle secretion"},{"relation":3214,"upstream_event_id":2063,"upstream_event":"Decrease, New cuticle secretion","downstream_event_id":990,"downstream_event":"Increase, Incomplete ecdysis"},{"relation":3215,"upstream_event_id":990,"upstream_event":"Increase, Incomplete ecdysis","downstream_event_id":2050,"downstream_event":"Increase, developmental abnormalities"},{"relation":3216,"upstream_event_id":2050,"upstream_event":"Increase, developmental abnormalities","downstream_event_id":350,"downstream_event":"Increase, Mortality"}]}