{"id":494,"title":"AhR activation leading to liver fibrosis ","short_name":"AhR and chronic liver diseases","created_at":"2023-04-13T08:31:32.000-04:00","updated_at":"2026-04-21T02:46:10.000-04:00","corresponding_author":{"id":16786,"created_at":"2023-03-31T16:57:39.000-04:00","updated_at":"2026-04-11T02:07:16.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":249,"stressor_name":"2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)"}],"aop_mies":[{"event_id":18,"event":"Activation, AhR","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":459,"event":"Increase, Liver steatosis","event_type":"KeyEvent"},{"event_id":55,"event":"Increase, Cell injury/death","event_type":"KeyEvent"},{"event_id":265,"event":"Increase, Hepatic stellate cell activation","event_type":"KeyEvent"},{"event_id":1501,"event":"Increase, Extracellular matrix deposition","event_type":"KeyEvent"}],"aop_aos":[{"event_id":344,"event":"Increase, Liver fibrosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":3857,"upstream_event_id":18,"upstream_event":"Activation, AhR","downstream_event_id":459,"downstream_event":"Increase, Liver steatosis"},{"relation":3856,"upstream_event_id":459,"upstream_event":"Increase, Liver steatosis","downstream_event_id":55,"downstream_event":"Increase, Cell injury/death"},{"relation":3419,"upstream_event_id":55,"upstream_event":"Increase, Cell injury/death","downstream_event_id":265,"downstream_event":"Increase, Hepatic stellate cell activation"},{"relation":3422,"upstream_event_id":265,"upstream_event":"Increase, Hepatic stellate cell activation","downstream_event_id":1501,"downstream_event":"Increase, Extracellular matrix deposition"},{"relation":3423,"upstream_event_id":1501,"upstream_event":"Increase, Extracellular matrix deposition","downstream_event_id":344,"downstream_event":"Increase, Liver fibrosis"}]}