{"id":497,"title":"ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome","short_name":"ERa inactivation leads to insulin resistance in skeletal muscle and metabolic syndrome","created_at":"2023-05-25T08:44:03.000-04:00","updated_at":"2024-07-04T12:38:30.000-04:00","corresponding_author":{"id":14127,"created_at":"2022-10-10T03:37:35.000-04:00","updated_at":"2025-11-21T05:05:47.000-05:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":2126,"event":"Estrogen receptor alpha inactivation","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":179,"event":"Decrease, Fatty acid beta-oxidation","event_type":"KeyEvent"},{"event_id":1115,"event":"Increase, Reactive oxygen species","event_type":"KeyEvent"},{"event_id":177,"event":"Increase, Mitochondrial dysfunction","event_type":"KeyEvent"},{"event_id":1392,"event":"Increase, Oxidative Stress ","event_type":"KeyEvent"},{"event_id":2144,"event":"Impaired insulin signaling","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2119,"event":"Increase, Insulin resistance","event_type":"AdverseOutcome"},{"event_id":2145,"event":"Metabolic syndrome","event_type":"AdverseOutcome"}],"relationships":[{"relation":3477,"upstream_event_id":2126,"upstream_event":"Estrogen receptor alpha inactivation","downstream_event_id":179,"downstream_event":"Decrease, Fatty acid beta-oxidation"},{"relation":3478,"upstream_event_id":2126,"upstream_event":"Estrogen receptor alpha inactivation","downstream_event_id":1115,"downstream_event":"Increase, Reactive oxygen species"},{"relation":3780,"upstream_event_id":179,"upstream_event":"Decrease, Fatty acid beta-oxidation","downstream_event_id":177,"downstream_event":"Increase, Mitochondrial dysfunction"},{"relation":3942,"upstream_event_id":1115,"upstream_event":"Increase, Reactive oxygen species","downstream_event_id":1392,"downstream_event":"Increase, Oxidative Stress "},{"relation":3782,"upstream_event_id":177,"upstream_event":"Increase, Mitochondrial dysfunction","downstream_event_id":2144,"downstream_event":"Impaired insulin signaling"},{"relation":3943,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":2144,"downstream_event":"Impaired insulin signaling"},{"relation":3804,"upstream_event_id":2144,"upstream_event":"Impaired insulin signaling","downstream_event_id":2119,"downstream_event":"Increase, Insulin resistance"},{"relation":3805,"upstream_event_id":2119,"upstream_event":"Increase, Insulin resistance","downstream_event_id":2145,"downstream_event":"Metabolic syndrome"},{"relation":3944,"upstream_event_id":1392,"upstream_event":"Increase, Oxidative Stress ","downstream_event_id":177,"downstream_event":"Increase, Mitochondrial dysfunction"}]}