{"id":502,"title":"Decrease, cholesterol synthesis leads to orofacial clefting","short_name":"Decrease, cholesterol synthesis leads to OFC","created_at":"2023-06-28T08:18:39.000-04:00","updated_at":"2023-08-31T09:40:10.000-04:00","corresponding_author":{"id":10937,"created_at":"2022-06-10T09:38:36.000-04:00","updated_at":"2026-02-07T10:04:26.000-05:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[],"aop_kes":[{"event_id":2041,"event":"Decrease, facial prominence outgrowth","event_type":"KeyEvent"},{"event_id":1821,"event":"Decrease, Cell proliferation","event_type":"KeyEvent"},{"event_id":2043,"event":"Decrease, Sonic Hedgehog second messenger production","event_type":"KeyEvent"},{"event_id":1262,"event":"Apoptosis","event_type":"KeyEvent"},{"event_id":2040,"event":"Decrease, GLI1/2 target gene expression","event_type":"KeyEvent"},{"event_id":2028,"event":"Decrease, GLI1/2 translocation to nucleus ","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2042,"event":"Increase, Orofacial clefting","event_type":"AdverseOutcome"}],"relationships":[]}