{"id":504,"title":"SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level","short_name":"SULT1E1 inhibition and increased oestradiol availability ","created_at":"2023-07-28T06:28:31.000-04:00","updated_at":"2025-04-03T15:56:08.000-04:00","corresponding_author":{"id":17647,"created_at":"2023-07-11T11:09:43.000-04:00","updated_at":"2025-07-23T12:41:53.000-04:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":4,"stressor_name":"17beta-Estradiol"},{"stressor_id":780,"stressor_name":"Polychlorinated biphenyls; mixture of specific PCBs"},{"stressor_id":261,"stressor_name":"Tetrabromobisphenol A"},{"stressor_id":782,"stressor_name":"1-Ethyl-1-nitrosourea"},{"stressor_id":603,"stressor_name":"Triclosan"},{"stressor_id":783,"stressor_name":"Cyclizine"},{"stressor_id":840,"stressor_name":"Redox status"}],"aop_mies":[{"event_id":2155,"event":"Inhibition of Sulfotransferase E1 (SULT1E1)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2251,"event":"Estradiol availability, increased","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1065,"event":"Activation, estrogen receptor alpha","event_type":"AdverseOutcome"}],"relationships":[{"relation":4117,"upstream_event_id":2155,"upstream_event":"Inhibition of Sulfotransferase E1 (SULT1E1)","downstream_event_id":2251,"downstream_event":"Estradiol availability, increased"},{"relation":4118,"upstream_event_id":2251,"upstream_event":"Estradiol availability, increased","downstream_event_id":1065,"downstream_event":"Activation, estrogen receptor alpha"}]}