{"id":508,"title":"Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway","short_name":"Nrf2 inhibition leading to vascular disrupting effects","created_at":"2023-08-20T02:18:45.000-04:00","updated_at":"2023-08-28T06:42:37.000-04:00","corresponding_author":{"id":17644,"created_at":"2023-07-09T02:21:52.000-04:00","updated_at":"2024-07-15T22:41:16.000-04:00","subscribed":true,"novice":true},"aop_stressors":[],"aop_mies":[{"event_id":1417,"event":"NFE2/Nrf2 repression","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2162,"event":"Activation, HIF1α","event_type":"KeyEvent"},{"event_id":2163,"event":"Activation Sema6A","event_type":"KeyEvent"},{"event_id":2164,"event":"Activation, Dll4-Notch pathway","event_type":"KeyEvent"},{"event_id":1928,"event":"increased，Vascular endothelial dysfunction","event_type":"KeyEvent"},{"event_id":2181,"event":"Angiogenesis dysfunction","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2161,"event":"Increase, Vascular disrupting effects","event_type":"AdverseOutcome"}],"relationships":[{"relation":3544,"upstream_event_id":1417,"upstream_event":"NFE2/Nrf2 repression","downstream_event_id":2162,"downstream_event":"Activation, HIF1α"},{"relation":3545,"upstream_event_id":2162,"upstream_event":"Activation, HIF1α","downstream_event_id":2163,"downstream_event":"Activation Sema6A"},{"relation":3546,"upstream_event_id":2163,"upstream_event":"Activation Sema6A","downstream_event_id":2164,"downstream_event":"Activation, Dll4-Notch pathway"},{"relation":3547,"upstream_event_id":2164,"upstream_event":"Activation, Dll4-Notch pathway","downstream_event_id":1928,"downstream_event":"increased，Vascular endothelial dysfunction"},{"relation":3617,"upstream_event_id":1928,"upstream_event":"increased，Vascular endothelial dysfunction","downstream_event_id":2181,"downstream_event":"Angiogenesis dysfunction"},{"relation":3618,"upstream_event_id":2181,"upstream_event":"Angiogenesis dysfunction","downstream_event_id":2161,"downstream_event":"Increase, Vascular disrupting effects"}]}