{"id":522,"title":"Estrogen antagonism leading to increased risk of autism-like behavior","short_name":"Estrogen antagonism leading to increased risk of autism-like behavior","created_at":"2024-01-25T09:48:07.000-05:00","updated_at":"2024-01-25T21:58:38.000-05:00","corresponding_author":{"id":9715,"created_at":"2022-04-11T09:30:48.000-04:00","updated_at":"2024-02-27T07:34:49.000-05:00","subscribed":true,"novice":true},"aop_stressors":[{"stressor_id":521,"stressor_name":"Bisphenol A"}],"aop_mies":[{"event_id":112,"event":"Antagonism, Estrogen receptor","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2207,"event":"inhibition, EKR1/2 signaling pathway","event_type":"KeyEvent"},{"event_id":195,"event":"Inhibition, NMDARs","event_type":"KeyEvent"},{"event_id":2208,"event":"Aberrant, synaptic formation and plasticity","event_type":"KeyEvent"},{"event_id":386,"event":"Decrease of neuronal network function","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2209,"event":"autism-like behavior","event_type":"AdverseOutcome"}],"relationships":[{"relation":3726,"upstream_event_id":112,"upstream_event":"Antagonism, Estrogen receptor","downstream_event_id":2207,"downstream_event":"inhibition, EKR1/2 signaling pathway"},{"relation":3727,"upstream_event_id":2207,"upstream_event":"inhibition, EKR1/2 signaling pathway","downstream_event_id":2208,"downstream_event":"Aberrant, synaptic formation and plasticity"},{"relation":3728,"upstream_event_id":2208,"upstream_event":"Aberrant, synaptic formation and plasticity","downstream_event_id":386,"downstream_event":"Decrease of neuronal network function"},{"relation":3729,"upstream_event_id":386,"upstream_event":"Decrease of neuronal network function","downstream_event_id":2209,"downstream_event":"autism-like behavior"},{"relation":3730,"upstream_event_id":195,"upstream_event":"Inhibition, NMDARs","downstream_event_id":2208,"downstream_event":"Aberrant, synaptic formation and plasticity"}]}